X0306 4 2014-07-01 0 0001157601 SYNTA PHARMACEUTICALS CORP SNTA 0001325713 Kovner Bruce C/O CAXTON CORPORATION 731 ALEXANDER ROAD, BLDG 2 PRINCETON NJ 08540 1 0 1 0 Common Stock 2014-07-01 4 A 0 9756 0 A 3058422 D Common Stock 2014-07-01 4 A 0 1219 0 A 3059641 D Common Stock 2014-07-01 4 A 0 1219 0 A 3060860 D Common Stock 8121467 I By KFO Holdings LLC Common Stock 5460000 I By OB Select Opportunities, LLC Common Stock 3100000 I By Kovner 2012 Family Trust B Common Stock 125000 I By Kovner 2011 Family Trust Common Stock 125000 I By Kovner 2011-B Investment Trust Common Stock 125000 I By Kovner 2011-C Investment Trust Common Stock 125000 I By Kovner 2011-D Investment Trust Common Stock 475000 I By Kovner 2012-A Synta Investment Trust Common Stock 475000 I By Kovner 2012-B Synta Investment Trust Common Stock 475000 I By Kovner 2012-C Synta Investment Trust Common Stock 475000 I By Kovner 2012-D Synta Investment Trust Common Stock 7761716 I By CxSynta LLC Director Stock Option (Right to Buy) 4.10 2014-07-01 4 A 0 10000 0 A 2024-07-01 Common Stock 10000 10000 D Represents a restricted stock grant subject to the Issuer's lapsing forfeiture right, which lapses as to 25% of the shares on each of September 30, 2014, December 31, 2014, March 31, 2015 and June 30, 2015, provided the Reporting Person continues to serve as a director of the Issuer on such date. Represents a restricted stock grant subject to the Issuer's lapsing forfeiture right, which lapses as to 25% of the shares on each of September 30, 2014, December 31, 2014, March 31, 2015 and June 30, 2015, provided the Reporting Person continues to serve as a member of the Compensation Committee of the Board of Directors of the Issuer on such date. Represents a restricted stock grant subject to the Issuer's lapsing forfeiture right, which lapses as to 25% of the shares on each of September 30, 2014, December 31, 2014, March 31, 2015 and June 30, 2015, provided the Reporting Person continues to serve as a member of the Nominating and Governance Committee of the Board of Directors of the Issuer on such date. These shares are owned directly by KFO Holdings LLC ("KFO") and indirectly by the Reporting Person as the sole member of KFO. These shares are owned directly by OB Select Opportunities, LLC and indirectly by the Reporting Person as chairman and sole shareholder of Caxton Corporation, the manager of OB Select Opportunities, LLC. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. These shares are owned directly by CxSynta LLC and indirectly by the Reporting Person as chairman and sole shareholder of Caxton Corporation, the managing member of CxSynta LLC. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of the beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. The option vests as to 25% of the shares on each of September 30, 2014, December 31, 2014, March 31, 2015 and June 30, 2015, provided the Reporting Person continues to serve as a director of the Issuer on such date. /s/ Heath Weisberg, Attorney-in-Fact 2014-07-03