X0306 4 2012-07-25 0 0001157601 SYNTA PHARMACEUTICALS CORP SNTA 0001325713 Kovner Bruce C/O CAXTON CORPORATION 731 ALEXANDER ROAD, BLDG 2 PRINCETON NJ 08540 1 0 1 0 Common Stock 2012-07-25 4 A 0 3081664 6.49 A 8006852 D Common Stock 125000 I By Kovner 2011-A Investment Trust Common Stock 125000 I By Kovner 2011-B Investment Trust Common Stock 125000 I By Kovner 2011-C Investment Trust Common Stock 125000 I By Kovner 2011-D Investment Trust Common Stock 475000 I By Kovner 2012-A Synta Investment Trust Common Stock 475000 I By Kovner 2012-B Synta Investment Trust Common Stock 475000 I By Kovner 2012-C Synta Investment Trust Common Stock 475000 I By Kovner 2012-D Synta Investment Trust Common Stock 7761716 I By CxSynta LLC These shares are owned directly by CxSynta LLC and indirectly by the Reporting Person as sole shareholder of Caxton Corporation, the managing member of CxSynta LLC. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of the beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. /s/ Scott B. Bernstein, Attorney-in-Fact 2012-07-27