The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aldeyra Therapeutics Inc COM 01438T106   27,322,824 5,475,516 SH   SOLE   5,475,516 0 0
Altimmune Inc COM NEW 02155H200   8,086,188 1,121,524 SH   SOLE   1,121,524 0 0
Applied Therapeutics Inc COM 03828A101   4,964,532 5,799,687 SH   SOLE   5,799,687 0 0
Avadel Pharmaceuticals Plc SPONSORED ADR 05337M104   6,306,000 600,000 SH   SOLE   600,000 0 0
HOOKIPA PHARMA COM 43906K100   1,002,236 498,625 SH   SOLE   498,625 0 0
Verona Pharma SPONSORED ADS 925050106   9,288,000 200,000 SH   SOLE   200,000 0 0
Biohaven Pharmactl Hldg Co L COM G11196105   28,401,761 760,422 SH   SOLE   760,422 0 0
Mereo Biopharma Group SPON ADS 589492107   911,645 260,470 SH   SOLE   260,470 0 0
MeiraGTX Holdings COM G59665102   7,612,500 1,250,000 SH   SOLE   1,250,000 0 0
Cardiol Therapeutics Inc COM Cal A 14161Y200   128,000 100,000 SH   SOLE   100,000 0 0
Booz Allen Hamilton HLDG COR CL A 099502106   1,673,100 13,000 SH   SOLE   13,000 0 0
Entera Bio Ltd SHS M40527109   12,469,583 5,881,879 SH   SOLE   5,881,879 0 0
Orgenesis, Inc. COM 68619K105   95,677 50,623 SH   SOLE   50,623 0 0
Grail Inc COM 384747101   1,785 100 SH   SOLE   100 0 0
Ocular Therapeutix Inc. COM 67576A100   5,127,416 600,400 SH   SOLE   600,400 0 0
Ocuphire Pharma Inc. COM 67577R102   53 45 SH   SOLE   45 0 0
Philip Morris Intl. Inc COM 718172109   1,203,500 10,000 SH   SOLE   10,000 0 0
Visa COM CL A 92826C839   1,532,794 4,850 SH   SOLE   4,850 0 0
SEABRIDGE GOLD INC COM 811916105   3,617,004 317,003 SH   SOLE   317,003 0 0
Silvercrest Metals Inc CAD COM 828363101   546,000 60,000 SH   SOLE   60,000 0 0
SKEENA RES LTD CAD COM 83056P715   2,750,288 315,400 SH   SOLE   315,450 0 0
iShares Silver Trust iShares 46428Q109   2,106,400 80,000 SH   SOLE   80,000 0 0
SPDR Gold Trust Gold SHS 78463V107   7,748,160 32,000 SH   SOLE   32,000 0 0
iSHares US Aerospace & Defense US AER DEF ETF 464288760   1,111,927 7,650 SH   SOLE   7,650 0 0
Northrop Grumman Corp COM 666807102   1,016,012 2,165 SH   SOLE   2,165 0 0
Agnico Eagle Mines Ltd COM 008474108   4,340,655 55,500 SH   SOLE   55,500 0 0
Alamos Gold Inc COM CL New 011532108   756,040 41,000 SH   SOLE   41,000 0 0
Equinox Gold Corp COM 29446Y502   2,765,071 550,811 SH   SOLE   550,811 0 0
Diageo PLC SPONS ADR NEW 25243Q205   858,127 6,750 SH   SOLE   6,750 0 0
Franco Nev Corp COM 351858105   2,939,750 25,000 SH   SOLE   25,000 0 0
Kinross Gold Corp COM 496902404   4,078,800 440,000 SH   SOLE   440,000 0 0
Mag Silver Corp COM 55903Q104   2,312,000 170,000 SH   SOLE   170,000 0 0
New Pac Metals Corp COM 64782A107   572,300 485,000 SH   SOLE   485,000 0 0
Royal Gold Inc. COM 780287108   995,467 7,550 SH   SOLE   7,550 0 0
Wheaton Precious Metals Corp COM 962879102   703,000 12,500 SH   SOLE   12,500 0 0