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Income Taxes - Schedule of Statutory Federal Income Tax Rate to Income from Continuing Operations Before Income Taxes (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Income tax (benefit) expense at the U.S. federal statutory rate of 21% $ (8) $ (662) $ 163
Foreign tax rate differential 3 16 40
U.S. federal research and development credit (27) (24) (25)
Excess tax benefits related to stock-based compensation (52) 6 (12)
Nondeductible compensation 42 15 13
Unrecognized tax benefits and related interest 6 36 17
Change in valuation allowance (24) 139 (2)
Return to provision true-ups 4 (20) (12)
State taxes (9) (48) 22
Non-deductible goodwill impairment 0 170 0
Divestitures and entity restructuring (6) (53) 0
Foreign-derived intangible income 0 0 (14)
Other, net 18 2 13
Income tax (benefit) expense $ (53) $ (423) $ 203