Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (82,383)	$ (80,154)
Adjustments to reconcile net loss to net cash used in operating activities:
Accretion of liability related to sale of future royalties	5,474	6,248
Accretion of debt discount and amortization of issuance costs	154	235
Depreciation and amortization	198	75
Share based compensation expense	7,124	6,566
Foreign currency adjustments	7,100	4,127
Changes in operating assets and liabilities:
Accounts receivable, net	1,276
Inventory	(1,908)
Prepaid expenses and other current assets	6,294	1,596
Other assets	474	159
Accounts payable	(1,026)	478
Accrued expenses	(12,074)	(1,103)
Other current and long-term liabilities	(2,504)	(4,412)
Net cash used in operating activities	(71,801)	(66,185)
Cash flows from investing activities:
Purchase of property and equipment	(920)	(279)
Net cash used in investing activities	(920)	(279)
Cash flows from financing activities:
Proceeds from exercise of options	6,181	1,627
Net cash provided by financing activities	6,181	1,627
Effect of exchange rate changes on cash and cash equivalents	(596)	(149)
Net decrease in cash and cash equivalents	(67,136)	(64,986)
Cash and cash equivalents - beginning of period	248,107	251,272
Cash and cash equivalents - end of period	$ 180,971	186,286
Supplemental disclosures of cash and non-cash activities
Fixed assets included in accrued expenses		$ 186