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                          August 23, 2022

       Ronald H.W. Cooper
       President and Chief Executive Officer
       Albireo Pharma, Inc.
       53 State Street, 19th Floor
       Boston, Massachusetts 02109

                                                        Re: Albireo Pharma,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed August 16,
2022
                                                            File No. 333-266893

       Dear Mr. Cooper:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              John P. Condon, Esq.