<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001651323</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001321732</issuerCik>
            <issuerName>PENUMBRA, INC.</issuerName>
            <secFileNumber>001-37557</secFileNumber>
            <issuerAddress>
                <ns2:street1>One Penumbra Place</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 748-3200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ADAM ELSESSER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>15800</noOfUnitsSold>
            <aggregateMarketValue>4260403.64</aggregateMarketValue>
            <noOfUnitsOutstanding>38999129</noOfUnitsOutstanding>
            <approxSaleDate>09/03/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/03/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15800</amountOfSecuritiesAcquired>
            <paymentDate>09/03/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/20/2025</saleDate>
            <amountOfSecuritiesSold>15900</amountOfSecuritiesSold>
            <grossProceeds>4046988.84</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/06/2025</saleDate>
            <amountOfSecuritiesSold>16030</amountOfSecuritiesSold>
            <grossProceeds>3818397.30</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/23/2025</saleDate>
            <amountOfSecuritiesSold>16150</amountOfSecuritiesSold>
            <grossProceeds>3765609.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/09/2025</saleDate>
            <amountOfSecuritiesSold>15985</amountOfSecuritiesSold>
            <grossProceeds>3896329.36</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/25/2025</saleDate>
            <amountOfSecuritiesSold>15890</amountOfSecuritiesSold>
            <grossProceeds>4026584.79</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ADAM ELSESSER</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2025</saleDate>
            <amountOfSecuritiesSold>15910</amountOfSecuritiesSold>
            <grossProceeds>4035902.43</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/03/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/25/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Adam Elsesser</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
