X0306 4 2022-03-04 0 0001850906 Singular Genomics Systems, Inc. OMIC 0001320267 Daly David 10931 N. TORREY PINES ROAD SUITE #100 LA JOLLA CA 92037 0 1 0 0 President and Chief Operating Employee Stock Option (right to buy) 7.50 2022-03-04 4 A 0 125000 0.00 A 2032-03-04 Common Stock 125000 0 D Employee Stock Option (right to buy) 7.50 2022-03-04 4 A 0 125000 0.00 A 2032-03-04 Common Stock 125000 0 D The option shares vest and become exercisable in 48 equal monthly installments measured from March 4, 2022. Subject to the achievement of certain performance targets by December 31, 2022, 25% of the option shares will vest and become exercisable on March 4, 2023, and the remaining option shares will vest and become exercisable in 36 equal monthly installments thereafter as the Reporting Person continues to provide services to the Issuer. /s/ Dalen Meeter, Attorney-in-Fact 2022-03-08