-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001460600-09-000001.txt : 20090403
<SEC-HEADER>0001460600-09-000001.hdr.sgml : 20090403
<ACCEPTANCE-DATETIME>20090403141236
ACCESSION NUMBER:		0001460600-09-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090403
DATE AS OF CHANGE:		20090403
EFFECTIVENESS DATE:		20090403

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CLEVELAND BIOLABS INC
		CENTRAL INDEX KEY:			0001318641
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				200077155
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-74314
		FILM NUMBER:		09731452

	BUSINESS ADDRESS:	
		STREET 1:		73 HIGH STREET
		CITY:			BUFFALO
		STATE:			NY
		ZIP:			14203
		BUSINESS PHONE:		(716) 849-6810

	MAIL ADDRESS:	
		STREET 1:		73 HIGH STREET
		CITY:			BUFFALO
		STATE:			NY
		ZIP:			14203
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001318641</cik>
        <entityName>CLEVELAND BIOLABS INC</entityName>
        <issuerAddress>
            <street1>73 HIGH STREET</street1>
            <street2></street2>
            <city>BUFFALO</city>
            <stateOrCountry>NY</stateOrCountry>
            <zipCode>14203</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(716) 849-6810</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName></middleName>
                <lastName>Fonstein</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yakov</firstName>
                <middleName></middleName>
                <lastName>Kogan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName></middleName>
                <lastName>Marhofer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrei</firstName>
                <middleName></middleName>
                <lastName>Gudkov</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <middleName></middleName>
                <lastName>DiCorleto</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bernard</firstName>
                <middleName></middleName>
                <lastName>Kasten</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daniel</firstName>
                <middleName></middleName>
                <lastName>Perez</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName></middleName>
                <lastName>Antal</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <street2></street2>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-03-20</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series D Convertible Preferred; Common Stock Purchase Warrants</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Garden State Securities, Inc.</recipientName>
                <recipientCRDNumber>10083</recipientCRDNumber>
                <associatedBDName>Garden State Securities, Inc.</associatedBDName>
                <associatedBDCRDNumber>10083</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>328 Newman Springs Road</street1>
                    <street2></street2>
                    <city>Red Bank</city>
                    <stateOrCountry>NJ</stateOrCountry>
                    <zipCode>07701</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>DE</state>
                    <state>DC</state>
                    <state>FL</state>
                    <state>GA</state>
                    <state>IL</state>
                    <state>IN</state>
                    <state>MA</state>
                    <state>MO</state>
                    <state>NH</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>PA</state>
                    <state>UT</state>
                    <state>WA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3726557</totalOfferingAmount>
            <totalAmountSold>3726557</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>43</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>372655</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CLEVELAND BIOLABS INC</issuerName>
                <signatureName>John A. Marhofer, Jr.</signatureName>
                <nameOfSigner>John A. Marhofer, Jr.</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-04-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----