Note 15 - Warrants (Details Textual) - $ / shares	Sep. 30, 2021	Dec. 31, 2020
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 4.82	$ 7.28
Class of Warrant or Right, Outstanding (in shares)	3,171,859	371,340
Avenue Capital Loan [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 0.01
Class of Warrant or Right, Outstanding (in shares)	154,004
GEM Agreement [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 5.01
Class of Warrant or Right, Outstanding (in shares)	1,720,083
Old Cytocom [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 5.23
Class of Warrant or Right, Outstanding (in shares)	902,000
Bridgeway Capital [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 2.94
Class of Warrant or Right, Outstanding (in shares)	96,263
Various Holders [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 5.62
Class of Warrant or Right, Outstanding (in shares)	299,519
Minimum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 0.01
Warrants and Rights Outstanding, Term (Year)	1 year
Maximum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 8.75
Warrants and Rights Outstanding, Term (Year)	7 years