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Note 3 - Merger with Old Cytocom (Details Textual) - USD ($)
2 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jul. 27, 2021
Sep. 30, 2021
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Jul. 26, 2021
Dec. 30, 2020
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)   $ 4.82 $ 4.82   $ 4.82   $ 7.28    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)   45,468 45,468   45,468   76,064    
Common Stock, Shares, Outstanding, Ending Balance (in shares) 15,478,945 32,095,520 32,095,520   32,095,520       13,376,062
Share Price (in dollars per share) $ 4.99                
Operating Expenses, Total     $ 9,764,542 $ 6,170,658 $ 21,282,059 $ 6,794,467      
Parent Company [Member]                  
Operating Expenses, Total   $ 200,000              
Avenue Warrants [Member]                  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) 154,004                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 0.01                
GEM Warrant [Member]                  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) 1,720,083                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 5.01                
Class of Warrant or Right, Percentage of Outstanding Securities Called by Warrants or Rights 4.99%                
Class of Warrant or Right, Exercise Price of Warrants or Rights, Contingent Increase (in dollars per share) $ 5.51                
Class of Warrant or Right, Exercise Price of Warrants or Rights, Contingent Increase, Period (Year) 1 year                
Share Price, Percentage of Exercise Price 90.00%                
2021 Warrants [Member]                  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)               952,000  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)               $ 5.00  
Cleveland BioLabs, Inc. [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares) 45,706                
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares (in shares) 45,706                
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price (in dollars per share) $ 14.46                
Merger Sub [Member] | Cytocom [Member]                  
Business Combination, Common Stock, Exchange Ratio (in shares) 0.3384                
Cytocom [Member]                  
Business Acquisition, Percentage of Voting Interests Acquired 46.00%                
Old Cytocom and ImQuest [Member]                  
Business Acquisition, Percentage of Voting Interests Acquired 54.00%                
Merger Agreement [Member]                  
Business Acquisition, Goodwill, Expected Tax Deductible Amount $ 0                
Business Combination, Acquisition Related Costs         970,000   $ 900,000    
Merger Agreement [Member] | General and Administrative Expense [Member]                  
Business Combination, Acquisition Related Costs         $ 800,000   $ 300,000