Note 9 - Commitments and Contingencies (Details Textual) - USD ($)	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018
Milestone Payment or Royalty on Net Sales Accrued	$ 0	$ 0
Unrecorded Unconditional Purchase Obligation, Total	23,650
Operating Lease, Expense	209,501	$ 398,346
Lessee, Operating Lease, Liability, Payments, Due, Total	$ 7,306

The amount of milestone payment or royalty on net sales accrued.

No definition available.

Name:	cbli_MilestonePaymentOrRoyaltyOnNetSalesAccrued
Namespace Prefix:	cbli_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

Amount of lessee's undiscounted obligation for lease payments for operating lease.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 842
-SubTopic 20
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918701-209980

+ Details

Name:	us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amount of operating lease expense. Excludes sublease income.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 842
-SubTopic 20
-Section 45
-Paragraph 4
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=77888419&loc=SL77918638-209977

+ Details

Name:	us-gaap_OperatingLeaseExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of the unrecorded obligation to transfer funds in the future for fixed or minimum amounts or quantities of goods or services at fixed or minimum prices (for example, as in take-or-pay contracts or throughput contracts).

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 440
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=77896938&loc=d3e25336-109308

+ Details

Name:	us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant