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Note 7 - Income Taxes (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
   
For the Year Ended December 31,
 
   
2019
   
2018
 
US operations
  $
(3,030,960
)   $
(3,345,925
)
Foreign operations
   
(131,704
)    
(361,522
)
    $
(3,162,664
)   $
(3,707,447
)
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
   
As of December 31,
 
   
2019
   
2018
 
Deferred tax assets:
               
Operating loss carryforwards
  $
36,577,000
    $
35,706,000
 
Accrued expenses
   
5,940,000
     
5,953,000
 
Tax credit carryforwards
   
4,017,000
     
3,951,000
 
Intellectual property
   
4,049,000
     
3,996,000
 
Equipment
   
71,000
     
110,000
 
Total deferred tax assets
   
50,654,000
     
49,716,000
 
Deferred tax liabilities:
   
     
 
Net deferred tax asset
   
50,654,000
     
49,716,000
 
Valuation allowance
   
(50,654,000
)    
(49,716,000
)
    $     $  
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
   
For the Year Ended December 31,
 
   
2019
   
2018
 
Tax at the U.S. statutory rate
  $
(664,000
)   $
(779,000
)
Change in value of warrant liability
   
(15,000
)    
(202,000
)
Valuation allowance
   
679,000
     
981,000
 
Other
   
     
 
    $     $  
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
   
Unrecognized Tax Benefits
   
Interest and Penalties
 
Balance at January 1, 2018
  $
493,000
    $
 
Deferred tax position
   
11,000
     
 
Balance at December 31, 2018
   
504,000
     
 
Deferred tax position
   
6,000
     
 
Balance at December 31, 2019
  $
510,000
    $