Note 8 - Income Taxes (Detail) - Deferred tax assets (liabilities) were comprised of the following as of the periods presented below: (USD $)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Deferred tax assets:
Operating loss carryforwards	$ 37,642,000	$ 28,972,000	$ 22,452,000
Accrued expenses	8,576,000	7,778,000	5,618,000
Tax credit carryforwards	2,921,000	2,537,000	2,217,000
Intellectual property	3,377,000	1,604,000	395,000
Outside tax basis difference in affiliate	1,616,000	1,378,000	472,000
Equipment	237,000	156,000	21,000
Other	4,000	4,000	4,000
Total deferred tax assets	54,373,000	42,429,000	31,179,000
Net deferred tax asset	54,373,000	42,429,000	31,179,000
Valuation allowance	$ (54,373,000)	$ (42,429,000)	$ (31,179,000)