<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001318641</cik>
        <entityName>CLEVELAND BIOLABS INC</entityName>
        <issuerAddress>
            <street1>73 HIGH STREET</street1>
            <city>BUFFALO</city>
            <stateOrCountry>NY</stateOrCountry>
            <zipCode>14203</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(716) 849-6810</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Fonstein</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrei</firstName>
                <lastName>Gudkov</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yakov</firstName>
                <lastName>Kogan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jack</firstName>
                <lastName>Marhofer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <lastName>DiCorleto</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Antal</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daniel</firstName>
                <lastName>Perez</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bernard</firstName>
                <middleName>L.</middleName>
                <lastName>Kasten</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>73 High Street</street1>
                <city>Buffalo</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>14203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-02</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Rodman &amp; Renshaw, LLC</recipientName>
                <recipientCRDNumber>16415</recipientCRDNumber>
                <associatedBDName>Rodman &amp; Renshaw, LLC</associatedBDName>
                <associatedBDCRDNumber>16415</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1251 Avenue of the Americas</street1>
                    <street2>20th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10020</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000000</totalOfferingAmount>
            <totalAmountSold>5000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>9</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>350000</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Rodman and Renshaw received approximately $350,000 in cash and Warrants to purchase 123,077 shares of Cleveland Biolabs, Inc. common stock at an exercise price of $4.50 per share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CLEVELAND BIOLABS INC</issuerName>
                <signatureName>/s/ Michael Fonstein</signatureName>
                <nameOfSigner>Michael Fonstein</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2010-03-05</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
