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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 TR7CtryGYHHeqaIOs9R8X2PAflmbH6VfR3AohbgiD4ieRktXCOMzq2Ey4GLA9Vux
 i1gdesMw11LDQXSSg/Iyyw==

<SEC-DOCUMENT>0001144204-06-029930.txt : 20060727
<SEC-HEADER>0001144204-06-029930.hdr.sgml : 20060727
<ACCEPTANCE-DATETIME>20060727143657
ACCESSION NUMBER:		0001144204-06-029930
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060725
FILED AS OF DATE:		20060727
DATE AS OF CHANGE:		20060727

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CLEVELAND BIOLABS INC
		CENTRAL INDEX KEY:			0001318641
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				200077155
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11000 CEDAR AVENUE
		STREET 2:		SUITE 290
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44106
		BUSINESS PHONE:		2162292251

	MAIL ADDRESS:	
		STREET 1:		11000 CEDAR AVENUE
		STREET 2:		SUITE 290
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44106

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ANTAL JAMES J
		CENTRAL INDEX KEY:			0001237871

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32954
		FILM NUMBER:		06984133

	BUSINESS ADDRESS:	
		STREET 1:		CENTERSTATE BANKS OF FLORIDA INC
		STREET 2:		7722 S.R. 544 E
		CITY:			WINTER HAVEN
		STATE:			FL
		ZIP:			33881
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>v048381_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-07-25</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001318641</issuerCik>
        <issuerName>CLEVELAND BIOLABS INC</issuerName>
        <issuerTradingSymbol>CBLI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001237871</rptOwnerCik>
            <rptOwnerName>ANTAL JAMES J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>30952 STEEPLECHASE DR.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN JUAN CAPISTRONO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92675</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>6.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-07-19</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">All options held by the reporting person were granted under the Cleveland Biolabs, Inc. Equity Incentive Plan and are fully
 vested. 15,000 options are currently exercisable.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ James J. Antal</signatureName>
        <signatureDate>2006-07-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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