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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PW71jdEWzuz2ZbuT+bDvlv7kXGF0seCtGkeym1o7ibWz+b+ZKfSVHVuSthPMg5+1
 Yku/FU9wyrTAl44d18e1+Q==

<SEC-DOCUMENT>0001104659-10-023454.txt : 20100429
<SEC-HEADER>0001104659-10-023454.hdr.sgml : 20100429
<ACCEPTANCE-DATETIME>20100429172840
ACCESSION NUMBER:		0001104659-10-023454
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100420
FILED AS OF DATE:		20100429
DATE AS OF CHANGE:		20100429

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Byrd Brett Alan
		CENTRAL INDEX KEY:			0001318051

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-21765
		FILM NUMBER:		10782963

	MAIL ADDRESS:	
		STREET 1:		23316 PORTLAND LANE
		CITY:			VALENCIA
		STATE:			CA
		ZIP:			91355

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Macquarie Global Infrastructure Total Return Fund Inc.
		CENTRAL INDEX KEY:			0001326390
		IRS NUMBER:				342045907

	BUSINESS ADDRESS:	
		STREET 1:		C/O MACQUARIE  FUND ADVISER, LLC
		STREET 2:		125 WEST 55TH STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		212-231-1572

	MAIL ADDRESS:	
		STREET 1:		C/O MACQUARIE  FUND ADVISER, LLC
		STREET 2:		125 WEST 55TH STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>a3.xml
<DESCRIPTION>3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-04-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001326390</issuerCik>
        <issuerName>Macquarie Global Infrastructure Total Return Fund Inc.</issuerName>
        <issuerTradingSymbol>MGU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001318051</rptOwnerCik>
            <rptOwnerName>Byrd Brett Alan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>555 SOUTH FLOWER ST.</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3300</rptOwnerStreet2>
            <rptOwnerCity>LOS ANGELES</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>90071</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Officer of Investment Adviser</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>MGU</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>/s/ Brett Alan Byrd</signatureName>
        <signatureDate>2010-04-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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