X0306 4 2019-06-11 0 0001510487 Principia Biopharma Inc. PRNB 0001316163 Colowick Alan C/O SOFINNOVA INVESTMENTS 3000 SAND HILL ROAD, 4-250 MENLO PARK CA 94025 1 0 0 0 Director Stock Option (right to buy) 31.77 2019-06-11 4 A 0 10240 0.00 A 2029-06-10 Common Stock 10240 10240 D The stock option vests in equal monthly installments over a one year period such that the option is fully vested on the first anniversary of the date of grant, subject to the continuing service of the Reporting Person on each vesting date. /s/ Christopher Y. Chai, Attorney-in-Fact for Alan Colowick 2019-06-11