144 0001315082 XXXXXXXX LIVE 0002036042 SIONNA THERAPEUTICS, INC. 001-42504 21 HICKORY DRIVE, SUITE 500 WALTHAM MA 02451 617-819-2020 RA Capital Healthcare Fund, L.P. Director 10% Stockholder Common Stock Goldman Sachs & Co

200 West St. New York NY 10282

3448811 21834318 45212399 09/17/2026 Nasdaq GM Common Stock 02/02/2022 Private Transaction Sionna Therapeutics N 606502 02/02/2022 Wire Common Stock 03/04/2024 Private Transaction Sionna Therapeutics N 1819723 03/04/2024 Wire Common Stock 02/07/2025 InitialPublic Offering Sionna Therapeutics N 1022586 02/07/2025 Wire Y 09/17/2026 /s/ Rajeev Shah