X0303 4 2008-12-22 0 0000875622 BIOSPECIFICS TECHNOLOGIES CORP BSTC 0001346824 RA CAPITAL MANAGEMENT, LLC C/O RA CAPITAL MANAGEMENT, LLC 800 BOYLSTON STREET, SUITE 1500 BOSTON MA 02199 0 0 1 0 0001315082 RA Capital Healthcare Fund LP C/O RA CAPITAL MANAGEMENT, LLC 800 BOYLSTON STREET, SUITE 1500 BOSTON MA 02199 0 0 1 0 0001392402 RA Capital Healthcare Fund II, L.P. C/O RA CAPITAL MANAGEMENT, LLC 800 BOYLSTON STREET, SUITE 1500 BOSTON MA 02199 0 0 1 0 0001384859 Kolchinsky Peter C/O RA CAPITAL MANAGEMENT, LLC 800 BOYLSTON STREET, SUITE 1500 BOSTON MA 02199 0 0 1 0 Common Stock 2008-12-22 4 P 0 350 18.75 A 774496 I see footnote Common Stock 2008-12-22 4 P 0 200 19.93 A 774696 I see footnote Common Stock 2008-12-22 4 P 0 1950 19.95 A 776646 I see footnote Common Stock 2008-12-22 4 P 0 2180 21.00 A 778826 I see footnote Common Stock 2008-12-22 4 P 0 170 19.90 A 778996 I see footnote Common Stock 2008-12-22 4 P 0 650 19.50 A 779646 I see footnote Common Stock 2008-12-23 4 P 0 500 20.00 A 780146 I see footnote Common Stock 2008-12-23 4 P 0 200 22.00 A 780346 I see footnote The acquired shares are divided between RA Capital Healthcare Fund, L.P. ("Fund I") and RA Capital Healthcare Fund II, L.P. ("Fund II") in a ratio of 99.25/0.75. RA Capital Management, LLC (the "General Partner") is the general partner of both Fund I and Fund II, and Peter Kolchinsky is the sole manager of the General Partner. Each of the Reporting Persons disclaims his or its beneficial ownership of any shares of the above named Issuer reported herein, except to the extent of his or its pecuniary interest therein. This number represents 771,245 shares held by Fund I and 9,101 shares held by Fund II. Peter Kolchinsky, Manager of RA Capital Management, LLC 2008-12-31 Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 2008-12-31 Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund II, L.P. 2008-12-31 Peter Kolchinsky 2008-12-31