X0202 4 2007-09-13 0 0001013238 ARADIGM CORP ARDM 0001346824 RA CAPITAL MANAGEMENT, LLC 111 HUNTINGTON AVE, STE 610 BOSTON MA 02199 0 0 1 0 0001315082 RA Capital Biotech Fund LP 111 HUNTINGTON AVENUE, SUITE 610 BOSTON MA 02199 0 0 1 0 0001392402 RA Capital Biotech Fund II, L.P. 111 HUNTINGTON AVE, STE 610 BOSTON MA 02199 0 0 1 0 0001185039 ALDRICH RICHARD C/O RA CAPITAL MANAGEMENT, LLC 111 HUNTINGTON AVE SUITE 610 BOSTON MA 02199 0 0 1 0 0001384859 Kolchinsky Peter C/O RA CAPITAL MANAGEMENT, LLC 111 HUNTINGTON AVE SUITE 610 BOSTON MA 02199 0 0 1 0 Common Stock 2007-09-13 4 P 0 110800 1.38 A 6854810 I see footnote The acquired shares represent 110,058 shares purchased by RA Capital Biotech Fund, LP ("Fund I") and 742 shares purchased by RA Capital Biotech Fund II, L.P. ("Fund II"). RA Capital Management, LLC (the General Partner") is the general partner of both Fund II and Fund I, and Richard H. Aldrich and Peter Kolchinsky are the sole managers of the General Partner. Each of the Reporting Persons disclaims his or its beneficial ownership of any shares of the above named Issuer reported herein, except to the extent of his or its pecuniary interest therein. /s/ Peter Kolchinsky Manager of RA Capital Management, LLC 2007-09-13 /s/ Peter Kolchinsky Manager of RA Capital Management, LLC the General Partner of RA Capital Biotech Fund, LP 2007-09-13 /s/ Peter Kolchinsky Manager of RA Capital Management, LLC the General Partner of RA Capital Biotech Fund II, LP 2007-09-13 /s/ Richard H. Aldrich 2007-09-13 /s/ Peter Kolchinsky 2007-09-13