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Bio-Techne Corp. 1.00000000 55.82500000 USD 2025-11-07 XXXX -5944.95000000 N N N SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 000000000 -39.00000000 NC USD -79853.94000000 -0.01534555399 N/A DE US N 2 SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 Call Written Cencora, Inc. Cencora, Inc. 100.00000000 301.00000000 USD 2025-11-04 XXXX -54473.65000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -47.00000000 NC USD -119145.00000000 -0.02289612799 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written HCA Healthcare, Inc. HCA Healthcare, Inc. 100.00000000 405.00000000 USD 2025-10-17 XXXX -57636.75000000 N N N Centene Corp 549300Z7JJ4TQSQGT333 15135B101 49135.00000000 NS USD 1753136.80000000 0.336900789499 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -103.00000000 NC USD -88580.00000000 -0.01702244339 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Rhythm Pharmaceuticals, Inc. 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Protagonist Therapeutics, Inc. 100.00000000 65.86000000 USD 2025-11-07 XXXX -15780.86000000 N N N BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 000000000 -3800.00000000 NC -95519.31000000 -0.01835597253 N/A DE US N 2 BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 Call Written UCB SA UCB SA 1.00000000 215.37300000 EUR 2025-10-21 XXXX -49537.84000000 N N N BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 000000000 -2700.00000000 NC -45207.48000000 -0.00868753408 N/A DE US N 2 BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 Call Written Zealand Pharma AS Zealand Pharma AS 1.00000000 354.79500000 DKK 2025-10-09 XXXX -33874.26000000 N N N BARCLAYS BANK PLC G5GSEF7VJP5I7OUK5573 000000000 -3800.00000000 NC USD -62013.34000000 -0.01191712090 N/A DE US N 2 BARCLAYS BANK PLC G5GSEF7VJP5I7OUK5573 Call Written West Pharmaceutical Services, Inc. West Pharmaceutical Services, Inc. 1.00000000 260.59000000 USD 2025-11-07 XXXX -7213.54000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -106.00000000 NC USD -5194.00000000 -0.00099813243 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Pfizer, Inc. Pfizer, Inc. 100.00000000 25.50000000 USD 2025-10-10 XXXX -950.21000000 N N N AFFINIVAX INC N/A 000000000 6331.00000000 NS USD 62676.90000000 0.012044637414 Long EC CORP US Y 3 N N N Guardant Health Inc 254900M8C3E5VC8BR186 40131M109 31531.00000000 NS USD 1970056.88000000 0.378586381982 Long EC CORP US N 1 N N N WaVe Life Sciences Ltd 54930070006GPKFYZ813 000000000 24727.00000000 NS USD 181001.64000000 0.034783135815 Long EC CORP SG N 1 N N N GOLDMAN SACHS INTERNATIONAL W22LROWP2IHZNBB6K528 000000000 -3900.00000000 NC -8665.94000000 -0.00166533611 N/A DE US N 2 GOLDMAN SACHS INTERNATIONAL W22LROWP2IHZNBB6K528 Call Written Galderma Group AG Galderma Group AG 1.00000000 141.67800000 CHF 2025-10-16 XXXX 11133.46000000 N N N Incyte Corp 549300Z4WN6JVZ3T4680 45337C102 33103.00000000 NS USD 2807465.43000000 0.539511417397 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -246.00000000 NC USD -27921.00000000 -0.00536558638 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Abbott Laboratories Abbott Laboratories 100.00000000 136.00000000 USD 2025-10-10 XXXX 23548.03000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -33.00000000 NC USD -69300.00000000 -0.01331740039 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Veeva Systems, Inc. Veeva Systems, Inc. 100.00000000 280.00000000 USD 2025-10-17 XXXX -48467.12000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -341.00000000 NC USD -81328.50000000 -0.01562892060 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Gilead Sciences, Inc. Gilead Sciences, Inc. 100.00000000 116.00000000 USD 2025-10-31 XXXX 13147.78000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -462.00000000 NC USD -35574.00000000 -0.00683626553 N/A DE IL N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Teva Pharmaceutical Industries Ltd. Teva Pharmaceutical Industries Ltd. 100.00000000 20.50000000 USD 2025-10-24 XXXX -15875.77000000 N N N NOMURA SECURITIES INTERNATIONAL INC OXTKY6Q8X53C9ILVV871 000000000 -29.00000000 NC USD -15521.15000000 -0.00298270373 N/A DE US N 2 NOMURA SECURITIES INTERNATIONAL INC OXTKY6Q8X53C9ILVV871 Call Written Disc Medicine, Inc. Disc Medicine, Inc. 100.00000000 65.00000000 USD 2025-11-07 XXXX -6682.63000000 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 000000000 32707.00000000 NS 5010744.91000000 0.962916251693 Long EC CORP GB N 2 N N N Intuitive Surgical Inc 54930052SRG011710797 46120E602 30454.00000000 NS USD 13619942.42000000 2.617348146613 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -69.00000000 NC USD -8280.00000000 -0.00159116991 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Summit Therapeutics, Inc. Summit Therapeutics, Inc. 100.00000000 21.00000000 USD 2025-10-17 XXXX -2982.81000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -29.00000000 NC USD -3770.00000000 -0.00072448195 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Scholar Rock Holding Corp. Scholar Rock Holding Corp. 100.00000000 40.00000000 USD 2025-10-17 XXXX 660.50000000 N N N JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 000000000 -19.00000000 NC USD -12086.34000000 -0.00232263534 N/A DE US N 2 JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 Call Written Charles River Laboratories International, Inc. Charles River Laboratories International, Inc. 100.00000000 162.00000000 USD 2025-11-04 XXXX -690.59000000 N N N Amgen Inc 62QBXGPJ34PQ72Z12S66 031162100 59717.00000000 NS USD 16852137.40000000 3.238479960502 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -24.00000000 NC USD -17040.00000000 -0.00327458156 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Vertex Pharmaceuticals, Inc. Vertex Pharmaceuticals, Inc. 100.00000000 397.50000000 USD 2025-10-17 XXXX -5063.36000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -104.00000000 NC USD -14040.00000000 -0.00269807072 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Cooper Cos., Inc. Cooper Cos., Inc. 100.00000000 70.00000000 USD 2025-10-17 XXXX -5769.24000000 N N N SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 000000000 -77.00000000 NC USD -6394.31000000 -0.00122879634 N/A DE US N 2 SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 Call Written Denali Therapeutics, Inc. Denali Therapeutics, Inc. 100.00000000 14.19000000 USD 2025-10-17 XXXX -1868.52000000 N N N Avidity Biosciences Inc N/A 05370A108 8950.00000000 NS USD 389951.50000000 0.074937088889 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -15.00000000 NC USD -22650.00000000 -0.00435265683 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written United Therapeutics Corp. United Therapeutics Corp. 100.00000000 410.00000000 USD 2025-10-17 XXXX -1669.22000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -276.00000000 NC USD -120750.00000000 -0.02320456129 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Merck & Co., Inc. Merck & Co., Inc. 100.00000000 81.00000000 USD 2025-10-24 XXXX -87039.67000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -132.00000000 NC USD -45540.00000000 -0.00875143454 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Exact Sciences Corp. Exact Sciences Corp. 100.00000000 54.00000000 USD 2025-10-31 XXXX -2999.10000000 N N N Labcorp Holdings Inc N/A 504922105 20462.00000000 NS USD 5873821.72000000 1.128773963816 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -35.00000000 NC USD -3150.00000000 -0.00060533638 N/A DE VG N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Biohaven Ltd. Biohaven Ltd. 100.00000000 20.00000000 USD 2025-10-17 XXXX -504.07000000 N N N CARBON HEALTH TECHNOLOGIES INC N/A 000000000 146331.67000000 NS USD 1463.32000000 0.000281206613 Long EC CORP US Y 3 N N N GOLDFINCH BIO INC N/A 000000000 190000.00000000 NS USD 76000.00000000 0.014604941269 Long EC CORP US Y 3 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -35.00000000 NC USD -2100.00000000 -0.00040355758 N/A DE VG N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Biohaven Ltd. Biohaven Ltd. 100.00000000 22.50000000 USD 2025-10-17 XXXX 7622.15000000 N N N Autolus Therapeutics PLC 549300C0KZP8EYROLL02 05280R100 64258.00000000 NS USD 104740.54000000 0.020128018885 Long EC CORP GB N 1 N N N Quanta Dialysis Technologies Ltd N/A 000000000 4243029.00000000 NS 302441.72000000 0.058120309975 Long EC CORP GB Y 3 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -68.00000000 NC USD -5440.00000000 -0.00104540632 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Bruker Corp. Bruker Corp. 100.00000000 35.00000000 USD 2025-10-17 XXXX 4608.81000000 N N N Abbott Laboratories HQD377W2YR662HK5JX27 002824100 231527.00000000 NS USD 31010726.38000000 5.959339967300 Long EC CORP US N 1 N N N Vaxcyte Inc 254900M7NMHTGASX8D95 92243G108 7730.00000000 NS USD 278434.60000000 0.053506855006 Long EC CORP US N 1 N N N JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 000000000 -12.00000000 NC USD -12669.42000000 -0.00243468598 N/A DE US N 2 JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 Call Written Repligen Corp. Repligen Corp. 100.00000000 130.00000000 USD 2025-11-07 XXXX -6600.10000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -74.00000000 NC USD -9250.00000000 -0.00177757508 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Biogen, Inc. Biogen, Inc. 100.00000000 150.00000000 USD 2025-10-17 XXXX 13617.96000000 N N N GE HealthCare Technologies Inc 549300OI9J7XOWZMUN85 36266G107 21440.00000000 NS USD 1610144.00000000 0.309421823104 Long EC CORP US N 1 N N N Bridgebio Pharma Inc 54930028YG89VTY2J114 10806X102 18507.00000000 NS USD 961253.58000000 0.184724369491 Long EC CORP US N 1 N N N Nuvalent Inc N/A 670703107 29333.00000000 NS USD 2536717.84000000 0.487481777254 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -372.00000000 NC USD -53010.00000000 -0.01018694653 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Bristol-Myers Squibb Co. Bristol-Myers Squibb Co. 100.00000000 45.00000000 USD 2025-11-07 XXXX -1089.04000000 N N N Kymera Therapeutics Inc N/A 501575104 4830.00000000 NS USD 273378.00000000 0.052535126769 Long EC CORP US N 1 N N N Stoke Therapeutics Inc 549300RD25SS2DIJHJ67 86150R107 69330.00000000 NS USD 1629255.00000000 0.313094389323 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -99.00000000 NC USD -41085.00000000 -0.00789531594 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Amgen, Inc. Amgen, Inc. 100.00000000 290.00000000 USD 2025-10-24 XXXX -2388.37000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -290.00000000 NC USD -14500.00000000 -0.00278646905 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Boston Scientific Corp. Boston Scientific Corp. 100.00000000 108.00000000 USD 2025-10-10 XXXX 37963.72000000 N N N Dexcom Inc 549300YSK3QDSFR5EU59 252131107 38114.00000000 NS USD 2564691.06000000 0.492857398770 Long EC CORP US N 1 N N N ADARX PHARMACEUTICALS INC N/A 000000000 52885.00000000 NS USD 628802.65000000 0.120837181231 Long EC CORP US Y 3 N N N Arcellx Inc N/A 03940C100 16531.00000000 NS USD 1357195.10000000 0.260812562200 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -29.00000000 NC USD -1885.00000000 -0.00036224097 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Glaukos Corp. Glaukos Corp. 100.00000000 90.00000000 USD 2025-10-17 XXXX 3886.77000000 N N N Pfizer Inc 765LHXWGK1KXCLTFYQ30 717081103 106328.00000000 NS USD 2709237.44000000 0.520634917068 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -44.00000000 NC USD -35200.00000000 -0.00676439385 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Thermo Fisher Scientific, Inc. Thermo Fisher Scientific, Inc. 100.00000000 500.00000000 USD 2025-10-17 XXXX 40868.00000000 N N N Bio-Techne Corp 54930073RLKQ51TILZ35 09073M104 17518.00000000 NS USD 974526.34000000 0.187274999494 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -36.00000000 NC USD -7020.00000000 -0.00134903536 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Biogen, Inc. Biogen, Inc. 100.00000000 149.00000000 USD 2025-10-24 XXXX 5289.06000000 N N N Edgewise Therapeutics Inc N/A 28036F105 22836.00000000 NS USD 370399.92000000 0.071179856288 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -185.00000000 NC USD -23125.00000000 -0.00444393772 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Stryker Corp. Stryker Corp. 100.00000000 390.00000000 USD 2025-10-17 XXXX 81061.45000000 N N N UCB SA 2138008J191VLSGY5A09 000000000 10073.00000000 NS 2811726.09000000 0.540330189622 Long EC CORP BE N 2 N N N Edwards Lifesciences Corp YA13X31F3V31L8TMPR58 28176E108 205137.00000000 NS USD 15953504.49000000 3.065789422691 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -146.00000000 NC USD -18615.00000000 -0.00357724975 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Becton Dickinson & Co. Becton Dickinson & Co. 100.00000000 195.00000000 USD 2025-10-17 XXXX 44278.32000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -194.00000000 NC USD -3395.00000000 -0.00065241810 N/A DE JE N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Novocure Ltd. Novocure Ltd. 100.00000000 15.00000000 USD 2025-10-17 XXXX 1411.65000000 N N N UBS AG BFM8T61CT2L1QCEMIK50 000000000 -1200.00000000 NC -1973.80000000 -0.00037930569 N/A DE US N 2 UBS AG BFM8T61CT2L1QCEMIK50 Call Written Galderma Group AG Galderma Group AG 1.00000000 148.08850000 CHF 2025-10-22 XXXX 4303.69000000 N N N Argenx SE 7245009C5FZE6G9ODQ71 04016X101 5763.00000000 NS USD 4250558.28000000 0.816830974255 Long EC CORP NL N 1 N N N Legend Biotech Corp 254900EIUFZTW136H859 52490G102 11174.00000000 NS USD 364384.14000000 0.070023802162 Long EC CORP KY N 1 N N N Cencora Inc AI8GXW8LG5WK7E9UD086 03073E105 26637.00000000 NS USD 8324861.61000000 1.599790985441 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -5.00000000 NC USD -7550.00000000 -0.00145088561 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Labcorp Holdings, Inc. Labcorp Holdings, Inc. 100.00000000 280.00000000 USD 2025-11-21 XXXX -2084.02000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -43.00000000 NC USD -9137.50000000 -0.00175595593 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written GE HealthCare Technologies, Inc. GE HealthCare Technologies, Inc. 100.00000000 75.00000000 USD 2025-10-17 XXXX -1751.11000000 N N N BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 000000000 -3300.00000000 NC -10667.72000000 -0.00205001873 N/A DE US N 2 BANK OF AMERICA NA B4TYDEB6GKMZO031MB27 Call Written AstraZeneca PLC AstraZeneca PLC 1.00000000 114.83160000 GBP 2025-11-04 XXXX 888.06000000 N N N Insmed Inc 529900Q55QAG41CCAC11 457669307 52511.00000000 NS USD 7562109.11000000 1.453212624047 Long EC CORP US N 1 N N N Arcus Biosciences Inc N/A 03969F109 26855.00000000 NS USD 365228.00000000 0.070185966974 Long EC CORP US N 1 N N N UBS AG BFM8T61CT2L1QCEMIK50 000000000 -23600.00000000 NC -7782.24000000 -0.00149551523 N/A DE US N 2 UBS AG BFM8T61CT2L1QCEMIK50 Call Written Daiichi Sankyo Co. Ltd. Daiichi Sankyo Co. Ltd. 1.00000000 3561.94130000 JPY 2025-11-05 XXXX 5576.60000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -115.00000000 NC USD -65550.00000000 -0.01259676184 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Intuitive Surgical, Inc. Intuitive Surgical, Inc. 100.00000000 465.00000000 USD 2025-10-17 XXXX 4091.03000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -263.00000000 NC USD -26300.00000000 -0.00505407836 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Stoke Therapeutics, Inc. Stoke Therapeutics, Inc. 100.00000000 25.00000000 USD 2025-10-17 XXXX 7305.23000000 N N N LB Pharmaceuticals Inc N/A 50180M108 48308.00000000 NS USD 762783.32000000 0.146584284081 Long EC CORP US N 1 N N Voyager Therapeutics Inc 54930082S4XVR0ZWCC74 92915B106 32205.00000000 NS USD 150397.35000000 0.028901900840 Long EC CORP US N 1 N N N Vir Biotechnology Inc N/A 92764N102 20570.00000000 NS USD 117454.70000000 0.022571302570 Long EC CORP US N 1 N N N MORGAN STANLEY & CO. INTERNATIONAL 4PQUHN3JPFGFNF3BB653 000000000 -300.00000000 NC USD -1321.42000000 -0.00025393765 N/A DE US N 2 MORGAN STANLEY & CO. INTERNATIONAL 4PQUHN3JPFGFNF3BB653 Call Written Natera, Inc. Natera, Inc. 1.00000000 179.01000000 USD 2025-11-07 XXXX 1480.94000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -413.00000000 NC USD -162102.50000000 -0.03115128279 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Abbott Laboratories Abbott Laboratories 100.00000000 134.00000000 USD 2025-10-31 XXXX -49373.54000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -227.00000000 NC USD -125985.00000000 -0.02421057270 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written UnitedHealth Group, Inc. UnitedHealth Group, Inc. 100.00000000 360.00000000 USD 2025-10-17 XXXX 176654.03000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -105.00000000 NC USD -10290.00000000 -0.00197743217 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Pfizer, Inc. 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Exact Sciences Corp. 100.00000000 52.50000000 USD 2025-10-17 XXXX -10932.56000000 N N N HCA Healthcare Inc 529900PH4ZGUH2MNEU89 40412C101 12565.00000000 NS USD 5355203.00000000 1.029110859250 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -18.00000000 NC USD -990.00000000 -0.00019024857 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Viking Therapeutics, Inc. Viking Therapeutics, Inc. 100.00000000 50.00000000 USD 2025-09-26 XXXX 7958.71000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -75.00000000 NC USD -937.50000000 -0.00018015963 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written BioMarin Pharmaceutical, Inc. BioMarin Pharmaceutical, Inc. 100.00000000 62.50000000 USD 2025-10-17 XXXX 10595.68000000 N N N Bio-Rad Laboratories Inc 549300ZC1GPV35XYDK53 090572207 2236.00000000 NS USD 626952.04000000 0.120481548989 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -22.00000000 NC USD -5841.00000000 -0.00112246660 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written CVS Health Corp. CVS Health Corp. 100.00000000 75.00000000 USD 2025-10-17 XXXX -2535.80000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -63.00000000 NC USD -160807.50000000 -0.03090242227 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Eli Lilly & Co. Eli Lilly & Co. 100.00000000 740.00000000 USD 2025-10-03 XXXX -82891.73000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -44.00000000 NC USD -302500.00000000 -0.05813150965 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written McKesson Corp. McKesson Corp. 100.00000000 710.00000000 USD 2025-10-31 XXXX -221445.15000000 N N N McKesson Corp 549300WZWOM80UCFSF54 58155Q103 11805.00000000 NS USD 9119834.70000000 1.752561186633 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -101.00000000 NC USD -19392.00000000 -0.00372656606 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written CVS Health Corp. CVS Health Corp. 100.00000000 77.00000000 USD 2025-10-24 XXXX -7193.57000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -70.00000000 NC USD -19775.00000000 -0.00380016728 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Agilent Technologies, Inc. Agilent Technologies, Inc. 100.00000000 130.00000000 USD 2025-10-17 XXXX -2704.03000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -86.00000000 NC USD -179310.00000000 -0.03445805288 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Insmed, Inc. Insmed, Inc. 100.00000000 125.00000000 USD 2025-10-17 XXXX -119215.68000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -43.00000000 NC USD -10965.00000000 -0.00210714711 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Natera, Inc. Natera, Inc. 100.00000000 170.00000000 USD 2025-10-17 XXXX 19039.36000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -140.00000000 NC USD -2800.00000000 -0.00053807678 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Boston Scientific Corp. Boston Scientific Corp. 100.00000000 105.00000000 USD 2025-10-17 XXXX 35389.10000000 N N N CG oncology Inc N/A 156944100 5223.00000000 NS USD 210382.44000000 0.040429252373 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -42.00000000 NC USD -2310.00000000 -0.00044391334 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Dexcom, Inc. Dexcom, Inc. 100.00000000 85.00000000 USD 2025-10-10 XXXX 3464.90000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -106.00000000 NC USD -28090.00000000 -0.00539806316 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Rhythm Pharmaceuticals, Inc. Rhythm Pharmaceuticals, Inc. 100.00000000 105.00000000 USD 2025-10-17 XXXX -1455.29000000 N N N Danaher Corp S4BKK9OTCEWQ3YHPFM11 235851102 44278.00000000 NS USD 8778556.28000000 1.686977617149 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -71.00000000 NC USD -31240.00000000 -0.00600339954 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Guardant Health, Inc. Guardant Health, Inc. 100.00000000 60.00000000 USD 2025-10-17 XXXX 6516.08000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -69.00000000 NC USD -15352.50000000 -0.00295029422 N/A DE IE N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Medtronic PLC Medtronic PLC 100.00000000 94.00000000 USD 2025-10-10 XXXX -3430.92000000 N N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 75886F107 8927.00000000 NS USD 5019384.29000000 0.964576483765 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -5.00000000 NC USD -1950.00000000 -0.00037473204 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Labcorp Holdings, Inc. Labcorp Holdings, Inc. 100.00000000 290.00000000 USD 2025-10-17 XXXX -910.13000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -60.00000000 NC USD -7920.00000000 -0.00152198861 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Merck & Co., Inc. Merck & Co., Inc. 100.00000000 87.00000000 USD 2025-10-24 XXXX -1533.08000000 N N N Summit Therapeutics Inc N/A 86627T108 18168.00000000 NS USD 375350.88000000 0.072131283657 Long EC CORP US N 1 N N N EXO IMAGING INC N/A 000000000 47496.39000000 NS USD 35147.33000000 0.006754272242 Long EC CORP US Y 3 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -127.00000000 NC USD -125095.00000000 -0.02403954115 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Amgen, Inc. Amgen, Inc. 100.00000000 285.00000000 USD 2025-11-07 XXXX -57340.38000000 N N N REGENXBIO Inc 549300EOES47LATSET33 75901B107 18875.00000000 NS USD 182143.75000000 0.035002615413 Long EC CORP US N 1 N N N Glaukos Corp 5299004JA1LHE21M6T14 377322102 7815.00000000 NS USD 637313.25000000 0.122472665614 Long EC CORP US N 1 N N N SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 000000000 -26.00000000 NC USD -11784.68000000 -0.00226466525 N/A DE US N 2 SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 Call Written Beam Therapeutics, Inc. Beam Therapeutics, Inc. 100.00000000 19.96000000 USD 2025-10-17 XXXX -9138.51000000 N N N Mettler-Toledo International Inc 5493000BD5GJNUDIUG10 592688105 870.00000000 NS USD 1068020.70000000 0.205241836821 Long EC CORP US N 1 N N N AFFERENT PHARMACEUTICAL N/A 000000000 190160.00000000 NS USD 1.90000000 0.000000365123 Long EP CORP US Y 3 N N N Teva Pharmaceutical Industries Ltd 549300BAFGM4RC74ZJ94 881624209 243163.00000000 NS USD 4911892.60000000 0.943919775615 Long EC CORP IL N 1 N N N BRIDGEBIO ONCOLOGY THERAPEUTICS INC N/A 000000000 15582.00000000 NS USD 180439.56000000 0.034675120744 Long EC CORP US Y 2 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -70.00000000 NC USD -7350.00000000 -0.00141245155 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Agilent Technologies, Inc. Agilent Technologies, Inc. 100.00000000 135.00000000 USD 2025-10-17 XXXX 383.29000000 N N N Alkermes PLC N/A 000000000 12700.00000000 NS USD 381000.00000000 0.073216876629 Long EC CORP IE N 1 N N N Elanco Animal Health Inc 549300SHPNDCE059M934 28414H103 42100.00000000 NS USD 847894.00000000 0.162940027276 Long EC CORP US N 1 N N N Merck & Co Inc 4YV9Y5M8S0BRK1RP0397 58933Y105 88682.00000000 NS USD 7443080.26000000 1.430338816631 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -156.00000000 NC USD -109590.00000000 -0.02105994097 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written AbbVie, Inc. AbbVie, Inc. 100.00000000 230.00000000 USD 2025-10-31 XXXX -46028.86000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -48.00000000 NC USD -8280.00000000 -0.00159116991 N/A DE IE N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Alkermes PLC Alkermes PLC 100.00000000 29.00000000 USD 2025-10-17 XXXX -4450.66000000 N N N Quest Diagnostics Inc 8MCWUBXQ0WE04KMXBX50 74834L100 24219.00000000 NS USD 4615657.02000000 0.886992101300 Long EC CORP US N 1 N N N STERIS PLC N/A 000000000 6027.00000000 NS USD 1491320.88000000 0.286587550880 Long EC CORP IE N 1 N N N Scholar Rock Holding Corp 549300Z1FLPGL4OWJ459 80706P103 14670.00000000 NS USD 546310.80000000 0.104984699329 Long EC CORP US N 1 N N N West Pharmaceutical Services Inc 5493007NKRGM1RJQ1P16 955306105 10207.00000000 NS USD 2677602.31000000 0.514555585283 Long EC CORP US N 1 N N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 69366J200 12726.00000000 NS USD 780994.62000000 0.150083954699 Long EC CORP US N 1 N N N KARTOS THERAPEUTICS INC N/A 000000000 85817.00000000 NS USD 487440.56000000 0.093671588833 Long STIV CORP US Y 3 N N N Waters Corp 5T547R1474YC9HOD8Q74 941848103 10495.00000000 NS USD 3146505.95000000 0.604664929012 Long EC CORP US N 1 N N N Eli Lilly & Co FRDRIPF3EKNDJ2CQJL29 532457108 53254.00000000 NS USD 40632802.00000000 7.808416932090 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -50.00000000 NC USD -2500.00000000 -0.00048042569 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Dexcom, Inc. Dexcom, Inc. 100.00000000 85.00000000 USD 2025-09-26 XXXX 5138.79000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -32.00000000 NC USD -16000.00000000 -0.00307472447 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Elevance Health, Inc. Elevance Health, Inc. 100.00000000 340.00000000 USD 2025-10-17 XXXX -1318.73000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -417.00000000 NC USD -237690.00000000 -0.04567695382 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Johnson & Johnson Johnson & Johnson 100.00000000 180.00000000 USD 2025-10-03 XXXX -139289.54000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -2.00000000 NC USD -955.00000000 -0.00018352261 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Mettler-Toledo International, Inc. Mettler-Toledo International, Inc. 100.00000000 1310.00000000 USD 2025-10-17 XXXX 3640.55000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -460.00000000 NC USD -324300.00000000 -0.06232082176 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Johnson & Johnson Johnson & Johnson 100.00000000 180.00000000 USD 2025-10-17 XXXX -157423.16000000 N N N SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 000000000 -58.00000000 NC USD -22623.13000000 -0.00434749322 N/A DE US N 2 SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 Call Written Ionis Pharmaceuticals, Inc. Ionis Pharmaceuticals, Inc. 100.00000000 65.01000000 USD 2025-10-17 XXXX -13008.09000000 N N N 4D Molecular Therapeutics Inc N/A 35104E100 11778.00000000 NS USD 102350.82000000 0.019668785723 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -19.00000000 NC USD -13870.00000000 -0.00266540178 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Neurocrine Biosciences, Inc. Neurocrine Biosciences, Inc. 100.00000000 135.00000000 USD 2025-10-17 XXXX -5287.06000000 N N N JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 000000000 -55.00000000 NC USD -1054.85000000 -0.00020271081 N/A DE US N 2 JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 Call Written WaVe Life Sciences Ltd. WaVe Life Sciences Ltd. 100.00000000 8.50000000 USD 2025-10-17 XXXX 4157.82000000 N N N Roivant Sciences Ltd 549300DL466NY5J6U724 000000000 42251.00000000 NS USD 639257.63000000 0.122846317663 Long EC CORP BM N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -38.00000000 NC USD -5890.00000000 -0.00113188294 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written GE HealthCare Technologies, Inc. GE HealthCare Technologies, Inc. 100.00000000 77.00000000 USD 2025-10-24 XXXX 1282.01000000 N N N IDEXX Laboratories Inc OGMTXK0LUU1HKV2P0J84 45168D104 6922.00000000 NS USD 4422396.58000000 0.849853188458 Long EC CORP US N 1 N N N Hologic Inc 549300DYP6F5ZJL0LB74 436440101 12498.00000000 NS USD 843490.02000000 0.162093713207 Long EC CORP US N 1 N N N JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 000000000 -55.00000000 NC USD -19371.94000000 -0.00372271113 N/A DE US N 2 JANE STREET EXECUTION SERVICES, LLC 549300HXJLXCPDWAH070 Call Written Incyte Corp. Incyte Corp. 100.00000000 86.25000000 USD 2025-11-07 XXXX 6080.77000000 N N N Bristol-Myers Squibb Co HLYYNH7UQUORYSJQCN42 110122108 97755.00000000 NS USD 4408750.50000000 0.847230817445 Long EC CORP US N 1 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -58.00000000 NC USD -242585.00000000 -0.04661762734 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Eli Lilly & Co. Eli Lilly & Co. 100.00000000 760.00000000 USD 2025-11-07 XXXX -123163.39000000 N N N INSITRO INC N/A 000000000 30616.00000000 NS USD 280442.56000000 0.053892725241 Long EC CORP US Y 3 N N N Allogene Therapeutics Inc N/A 019770106 108101.00000000 NS USD 134045.24000000 0.025759511285 Long EC CORP US N 1 N N Gilead Sciences Inc 549300WTZWR07K8MNV44 375558103 89782.00000000 NS USD 9965802.00000000 1.915130959431 Long EC CORP US N 1 N N N BARCLAYS BANK PLC G5GSEF7VJP5I7OUK5573 000000000 -9100.00000000 NC -22672.46000000 -0.00435697298 N/A DE US N 2 BARCLAYS BANK PLC G5GSEF7VJP5I7OUK5573 Call Written AstraZeneca PLC AstraZeneca PLC 1.00000000 115.28140000 GBP 2025-10-28 XXXX 19386.45000000 N N N SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 000000000 -26.00000000 NC USD -78874.15000000 -0.01515726747 N/A DE US N 2 SUSQUEHANNA FINANCIAL GROUP LLLP 549300E8QX0ZMRDC2M81 Call Written IDEXX Laboratories, Inc. IDEXX Laboratories, Inc. 100.00000000 643.00000000 USD 2025-11-10 XXXX 17450.04000000 N N N Options Clearing Corp. 549300CII6SLYGKNHA04 000000000 -16.00000000 NC USD -4080.00000000 -0.00078405474 N/A DE US N 1 Options Clearing Corp. 549300CII6SLYGKNHA04 Call Written Regeneron Pharmaceuticals, Inc. Regeneron Pharmaceuticals, Inc. 100.00000000 615.00000000 USD 2025-10-17 XXXX 17759.41000000 N N N 2025-10-29 BlackRock Health Sciences Trust Chuck Pulsfort Chuck Pulsfort Assistant Treasurer XXXX