X0303 4 2009-12-12 0000729922 OSI PHARMACEUTICALS INC OSIP 0001314821 LUNDEMOSE ANKER MD, PH.D, DSC C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD NEW YORK NY 11747 1 EVP, Corp. Dev & Strategic Pln Common Stock 2009-12-12 4 F 0 892 34.75 D 26687 D Common Stock 2009-12-13 4 F 0 815 34.75 D 25872 D Reflects the withholding of shares by the Company to satisfy the tax liability upon the vesting of Restricted Stock Units. /s/ Pierre Legault, attorney-in-fact for Dr. Lundemose 2009-12-15