Share-Based Payment Awards - Stock Option Activity Under Company's Equity Incentive Plan (Detail) - Equity Incentive Plan and Inducement Awards [Member] $ / shares in Units, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2025 USD ($) $ / shares shares	Dec. 31, 2024 USD ($) $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, Beginning balance | shares	7,670,647
Number of Options, Granted | shares	2,366,135
Number of Options, Exercised | shares	(132,991)
Number of Options, Forfeited | shares	(265,829)
Number of Options, Expired | shares	(162,331)
Number of Options Outstanding, Ending balance | shares	9,475,631	7,670,647
Number of Options, Exercisable at June 30, 2025 | shares	4,520,671
Weighted Average Exercise Price Outstanding, Beginning balance | $ / shares	$ 12.47
Weighted Average Exercise Price, Granted | $ / shares	8
Weighted Average Exercise Price, Exercised | $ / shares	3.74
Weighted Average Exercise Price, Forfeited | $ / shares	11.06
Weighted Average Exercise Price, Expired | $ / shares	21.13
Weighted Average Exercise Price Outstanding, Ending balance | $ / shares	11.37	$ 12.47
Weighted Average Exercise Price, Exercisable at June 30, 2025 | $ / shares	$ 12.57
Weighted Average Remaining Contractual Life, Outstanding at June 30, 2025	7 years 7 months 20 days	7 years 5 months 4 days
Weighted Average Remaining Contractual Life, Exercisable at June 30, 2025	6 years 3 months 14 days
Aggregate Intrinsic Value, Outstanding at June 30, 2025 | $	$ 14,213	$ 7,478
Aggregate Intrinsic Value, Exercisable at June 30, 2025 | $	$ 6,590