Share-Based Payment Awards - Stock Option Activity Under Company's Equity Incentive Plan (Detail) - Equity Incentive Plan and Inducement Awards [Member] - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2025	Dec. 31, 2024
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, Beginning balance	7,670,647
Number of Options, Granted	2,142,935
Number of Options, Exercised	(68,779)
Number of Options, Forfeited	(187,786)
Number of Options, Expired	(162,331)
Number of Options Outstanding, Ending balance	9,394,686	7,670,647
Number of Options, Exercisable at March 31, 2025	4,262,537
Weighted Average Exercise Price Outstanding, Beginning balance	$ 12.47
Weighted Average Exercise Price, Granted	8.21
Weighted Average Exercise Price, Exercised	3.26
Weighted Average Exercise Price, Forfeited	10.64
Weighted Average Exercise Price, Expired	21.13
Weighted Average Exercise Price Outstanding, Ending balance	11.46	$ 12.47
Weighted Average Exercise Price, Exercisable at March 31, 2025	$ 12.51
Weighted Average Remaining Contractual Life, Outstanding at March 31, 2025	7 years 9 months 18 days	7 years 5 months 4 days
Weighted Average Remaining Contractual Life, Exercisable at March 31, 2025	6 years 4 months 9 days
Aggregate Intrinsic Value, Outstanding at March 31, 2025	$ 3,473	$ 7,478
Aggregate Intrinsic Value, Exercisable at March 31, 2025	$ 2,032