Share-Based Payment Awards - Stock Option Activity Under Company's Equity Incentive Plan (Detail) - Equity Incentive Plans and Inducement Awards [Member] $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($) $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, Beginning balance | shares	4,082,555
Number of Options, Granted | shares	2,923,861
Number of Options, Exercised | shares	(260,321)
Number of Options, Forefeited | shares	(385,075)
Number of Options, Expired | shares	(56,253)
Number of Options Outstanding, Ending balance | shares	6,304,767
Number of Options, Exercisable at December 31, 2023 | shares	2,325,480
Weighted Average Exercise Price Outstanding, Beginning balance | $ / shares	$ 13.79
Weighted Average Exercise Price, Granted | $ / shares	4.76
Weighted Average Exercise Price, Exercised | $ / shares	11.33
Weighted Average Exercise Price, Forefeited | $ / shares	7.38
Weighted Average Exercise Price, Expired | $ / shares	26.71
Weighted Average Exercise Price Outstanding, Ending balance | $ / shares	9.98
Weighted Average Exercise Price, Exercisable at December 31, 2023 | $ / shares	$ 15.61
Weighted Average Remaining Contractual Life, Outstanding at December 31, 2023	7 years 10 months 20 days
Weighted Average Remaining Contractual Life, Exercisable at December 31, 2023	6 years 3 months 21 days
Aggregate Intrinsic Value, Outstanding at December 31, 2023 | $	$ 85,536
Aggregate Intrinsic Value, Exercisable at December 31, 2023 | $	$ 20,178