Share-Based Payment Awards - Stock Option Activity Under Company's Equity Incentive Plan (Detail) - Equity Incentive Plan and Inducement Awards [Member] - USD ($) $ / shares in Units, $ in Thousands	9 Months Ended
	Sep. 30, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, Beginning balance	4,082,555
Number of Options, Granted	2,739,861
Number of Options, Exercised	(56,090)
Number of Options, Forfeited	(373,911)
Number of Options, Expired	(51,753)
Number of Options Outstanding, Ending balance	6,340,662
Number of Options, Exercisable at September 30, 2023	2,354,229
Weighted Average Exercise Price Outstanding, Beginning balance	$ 13.79
Weighted Average Exercise Price, Granted	4.28
Weighted Average Exercise Price, Exercised	11.31
Weighted Average Exercise Price, Forfeited	7.01
Weighted Average Exercise Price, Expired	25.98
Weighted Average Exercise Price Outstanding, Ending balance	10
Weighted Average Exercise Price, Exercisable at September 30, 2023	$ 15.69
Weighted Average Remaining Contractual Life, Outstanding at September 30, 2023	8 years 25 days
Weighted Average Remaining Contractual Life, Exercisable at September 30, 2023	6 years 6 months 14 days
Aggregate Intrinsic Value, Outstanding at September 30, 2023	$ 10,437
Aggregate Intrinsic Value, Exercisable at September 30, 2023	$ 42