Fair Value Measurements - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Feb. 13, 2019
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities	$ 48,928,000	$ 32,965,000
Interest-bearing cash equivalent consisted of money market fund	77,200,000	155,600,000
Interest-bearing cash equivalent consisted of investment-grade commercial paper		16,500,000
Interest-bearing cash equivalent consisted of investment-grade U.S.Treasury securities	5,000,000.0
Carrying value of loan	30,000,000
CRG Servicing LLC [Member] | Senior Secured Term Loan [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Carrying value of loan	0	38,900,000
long-term debt		36,600,000
Exit fee accrued			$ 2,100,000
Fair value of loan	0	38,700,000
CRG Servicing LLC [Member] | Other Long-term Liabilities [Member] | Senior Secured Term Loan [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Exit fee accrued		$ 2,300,000
DEXYCU [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Impairment charges	$ 20,700,000
Investment Instruments [Member] | Credit Concentration Risk [Member] | Money Market Funds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Percentage of concentration risk	93.90%	90.40%
Investment Instruments [Member] | Credit Concentration Risk [Member] | Commercial Paper [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Percentage of concentration risk		9.60%
Investment Instruments [Member] | Credit Concentration Risk [Member] | US Treasury Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Percentage of concentration risk	6.10%