CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Income [Member]
Balance at Dec. 31, 2020	$ 18,541	$ 18	$ 528,362	$ (510,680)	$ 841
Balance, shares at Dec. 31, 2020		18,139,981
Net loss	(58,417)			(58,417)
Issuance of stock and pre-funded warrants, net of issue costs	216,586	$ 16	216,570
Issuance of stock and pre-funded warrants, net of issue costs, shares		15,635,811
Employee stock purchase plan	273		273
Employee stock purchase plan, shares		43,365
Exercise of stock options	100		100
Exercise of stock options, shares		8,112
Vesting of stock units	(150)		(150)
Vesting of stock units, shares		78,557
Stock-based compensation	7,447		7,447
Balance at Dec. 31, 2021	$ 184,380	$ 34	752,602	(569,097)	841
Balance, shares at Dec. 31, 2021	33,905,826	33,905,826
Net loss	$ (102,254)			(102,254)
Other comprehensive loss	(55)				(55)
Issuance of stock, net of issue costs	20		20
Employee stock purchase plan	354		354
Employee stock purchase plan, shares		47,787
Exercise of stock options	41		41
Exercise of stock options, shares		4,479
Vesting of stock units	(295)		(295)
Vesting of stock units, shares		124,842
Stock-based compensation	14,177		14,177
Balance at Dec. 31, 2022	$ 96,368	$ 34	$ 766,899	$ (671,351)	$ 786
Balance, shares at Dec. 31, 2022	34,082,934	34,082,934