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Debt and Warrants - Schedule of Future Minimum Payments under Oxford Loan (Detail) - USD ($)
$ in Thousands
Dec. 31, 2015
May. 04, 2015
Dec. 31, 2014
Jun. 30, 2014
Debt Instrument [Line Items]        
Present value of loan payments   $ 43,000    
Oxford Finance Term Loan [Member]        
Debt Instrument [Line Items]        
2016 $ 1,043      
2017 6,554      
2018 6,554      
2019 4,031      
Total future minimum payments 18,182      
Less: unamortized interest (2,427)      
Less: exit fee (755)   $ (600)  
Present value of loan payments $ 15,000   $ 15,000 $ 15,000