Accrued interest.

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Debt instrument prepayment fee percentage.

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Percentage of exit fee.

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Proceeds of term loan used to repay existing loan.

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Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense.

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Amount of noncash expense included in interest expense to allocate debt discount and premium, and the costs to issue debt and obtain financing over the related debt instruments. Alternate captions include noncash interest expense.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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- Definition

The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period.

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The number of warrants issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period.

+ References

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Amount of a favorable spread to a debt holder between the amount of debt being converted and the value of the securities received upon conversion. This is an embedded conversion feature of convertible debt issued that is in-the-money at the commitment date.

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The price per share of the conversion feature embedded in the debt instrument.

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Face (par) amount of debt instrument at time of issuance.

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Contractual interest rate for funds borrowed, under the debt agreement.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

+ References

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Description of the payment terms of the debt instrument (for example, whether periodic payments include principal and frequency of payments) and discussion about any contingencies associated with the payment.

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Period of time between issuance and maturity of debt instrument, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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No definition available.

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Amount of debt issuance costs (for example, but not limited to, legal, accounting, broker, and regulatory fees).

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No definition available.

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Describe the conversion features of preferred stock if preferred stock is convertible. That is, shares of preferred stock into which another convertible security was converted, or shares of preferred stock into which another class of preferred stock was converted.

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The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer.

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- Definition

Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Description of the reverse stock split arrangement. Also provide the retroactive effect given by the reverse split that occurs after the balance sheet date but before the release of financial statements.

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Debt and Warrants - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		6 Months Ended	12 Months Ended
	May. 04, 2015	Jun. 30, 2014	Nov. 30, 2011	Jun. 30, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Mar. 31, 2015
Debt Instrument [Line Items]
Convertible debt, principal amount	$ 43,000
Convertible notes, accrued interest	5,222					$ 4,153
Contingent beneficial conversion feature					$ 396		$ 1,123
Amortization of debt discount					483	1,070	1,257
March 2015 Convertible Notes [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount	13,000
Convertible notes, accrued interest	168
Contingent beneficial conversion feature	$ 400
Conversion price	$ 11.81
Warrant issued in connection with convertible notes	0
Square 1 Bank [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount			$ 4,000
Repayments of debt		$ 4,000
Debt instrument term			3 years
Oxford Finance Term Loan [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount		$ 15,000		$ 15,000	$ 15,000	15,000
Debt instrument term				5 years
Interest rate		6.954%		6.954%
Maturity date				Jun. 01, 2019
Exit fee percentage		5.00%		5.00%
Loan origination fees				$ 100
Debt issuance costs				$ 100
Debt instrument prepayment description					The Company is permitted to make voluntary prepayments of the Oxford Loan with a prepayment fee, calculated as of the loan origination date, equal to (i) 3.0% of the loan prepaid during the first 12 months, (ii) 2.0% of the loan prepaid in months 13-24 and (iii) 1.0% of the loan thereafter.
Amortization of debt discount					$ 1,300	$ 700	$ 0
Proceeds of term loan used to pay off existing term loan with Square 1 Bank					$ 800
Oxford Finance Term Loan [Member] \| Loan Prepaid During First 12 Months [Member]
Debt Instrument [Line Items]
Debt instrument prepayment fee percentage					3.00%
Oxford Finance Term Loan [Member] \| Loan Prepaid During 13 to 24 Months [Member]
Debt Instrument [Line Items]
Debt instrument prepayment fee percentage					2.00%
Oxford Finance Term Loan [Member] \| Loan Prepaid After 24 Months [Member]
Debt Instrument [Line Items]
Debt instrument prepayment fee percentage					1.00%
Comerica Bank [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount								$ 4,500
Reverse stock split					one for nine
Reverse stock split ratio					0.1111
Comerica Bank [Member] \| Common Class Undefined [Member]
Debt Instrument [Line Items]
Issuance of warrants to purchase of stock					1,039
Warrant price per share					$ 108.18
Series B Preferred Stock [Member] \| Square 1 Bank [Member]
Debt Instrument [Line Items]
Issuance of warrants to purchase of stock					11,835
Warrant price per share					$ 10.14
Series B Preferred Stock [Member] \| Oxford Finance L L C
Debt Instrument [Line Items]
Issuance of warrants to purchase of stock					51,783
Warrant price per share					$ 10.14
Private Tobira’s Convertible Notes [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount	$ 43,000
Convertible notes, accrued interest	5,200
Private Tobira’s Convertible Notes [Member] \| Related Party [Member]
Debt Instrument [Line Items]
Convertible debt, principal amount	36,000
Convertible notes, accrued interest	$ 5,100
Private Tobira’s Convertible Notes [Member] \| Series B Preferred Stock [Member]
Debt Instrument [Line Items]
Debt conversion, converted instrument, shares issued	3,532,756
Preferred stock, conversion basis					one for one