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Business combination common stock exchange ratio.

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Significant accounting policies.

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Face amount or stated value per share of common stock.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Topic 210
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-Section S99
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Total loss recognized during the period from the impairment of goodwill plus the loss recognized in the period resulting from the impairment of the carrying amount of intangible assets, other than goodwill.

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The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of an intangible asset (excluding goodwill) to fair value.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Description of the reverse stock split arrangement. Also provide the retroactive effect given by the reverse split that occurs after the balance sheet date but before the release of financial statements.

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Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Millions					9 Months Ended	12 Months Ended
	Nov. 30, 2015 USD ($)	Nov. 16, 2015 USD ($)	May. 04, 2015	Jul. 28, 2014	Sep. 30, 2015 USD ($)	Dec. 31, 2015 $ / shares	Dec. 31, 2014 $ / shares
Significant Accounting Policies [Line Items]
Common stock, par value \| $ / shares						$ 0.001	$ 0.0001
Impairment to goodwill					$ 5.1
Minimum [Member]
Significant Accounting Policies [Line Items]
Property, plant and equipment useful lives						3 years
Maximum [Member]
Significant Accounting Policies [Line Items]
Property, plant and equipment useful lives						5 years
Duke University [Member]
Significant Accounting Policies [Line Items]
Additional payment under license agreement to release financial obligation	$ 0.1	$ 0.1
In Process Research and Development [Member]
Significant Accounting Policies [Line Items]
Impairment of intangible assets					$ 12.2
Tobira Therapeutics Inc [Member]
Significant Accounting Policies [Line Items]
Reverse stock split						one for 26.4065866
Reverse stock split ratio				0.0378693
Regado [Member]
Significant Accounting Policies [Line Items]
Reverse stock split						one for nine
Reverse stock split ratio			0.1111
Debt conversion, converted instrument, shares issued						1.4302
Common stock, par value \| $ / shares						$ 0.001