X0306 4 2015-05-04 0 0001311596 Tibira Therapeutics, Inc. TBRA 0001379344 Fischer Laurent C/O TOBIRA THERAPEUTICS, INC. 701 GATEWAY BOULEVARD #300 SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Executive Officer Stock Options (right to buy) 2.96 2015-05-04 4 A 0 4332 0.00 A 2019-04-27 Common Stock 4332 4332 D Stock Options (right to buy) 3.14 2015-05-04 4 A 0 4332 0.00 A 2020-09-22 Common Stock 4332 8664 D Stock Options (right to buy) 3.14 2015-05-04 4 A 0 53616 0.00 A 2020-11-30 Common Stock 53616 62280 D Stock Options (right to buy) 3.14 2015-05-04 4 A 0 16416 0.00 A 2021-05-31 Common Stock 16416 78696 D Stock Options (right to buy) 3.51 2015-05-04 4 A 0 6769 0.00 A 2013-02-06 Common Stock 6769 85465 D Stock Options (right to buy) 4.81 2015-05-04 4 A 0 83324 0.00 A 2024-04-27 Common Stock 83324 168789 D Stock Options (right to buy) 4.81 2015-05-04 4 A 0 503882 0.00 A 2015-04-27 Common Stock 503882 672671 D Reporting Person received such stock option in exchange for a stock option to purchase Tobira Therapeutics, Inc. ("Tobira") common stock in connection with the merger of Tobira into Issuer (the "Merger"). Pursuant to the terms of the Merger agreement each Tobira stock option assumed will be determined by multiplying the number of options by the exchange ratio of 1.43 and rounding down to the nearest whole number. The shares are fully vested and exercisable at any time. 16,074 of the option share are vested and exercisable at any time. The remaining 342 shares will vest and become exercisable on June 1, 2015, subject to the terms of the Issuer's 2010 Stock Plan. These shares shall never vest or become exercisable. 11,572 shares are vested and exercisable at any time. The remaining shares will vest and become exercisable accordingly: 1,157 shares on the 17th of each month from May 17, 2015 through December 17, 2015; 1,735 on the 17th of each month from January 17, 2016 through December 17, 2016; 6,944 on the 17th of each month from January 17, 2017 through March 17, 2018, subject to the terms of the Issuer's 2010 Stock Plan. 147,461 shares are vested and exercisable at any time. The remaining shares will vest and become exercisable accordingly: 11,076 shares on the 17th of each month from May 17, 2015 through December 17, 2015; 10,496 on the 17th of each month from January 17, 2016 through December 17, 2017; 5,289 on the 17th of each month from January 17, 2018 through March 17, 2018, subject to the terms of the Issuer's 2010 Stock Plan. /s/ Christopher Reilly, attorney-in-fact 2015-05-06