X0306 4 2015-05-04 0 0001311596 Tibira Therapeutics, Inc. TBRA 0001614740 Peetz Christopher C/O TOBIRA THERAPEUTICS, INC. 701 GATEWAY BOULEVARD SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Financial Officer Stock Options (right to buy) 4.81 2015-05-06 4 A 0 68732 0.00 A 2024-04-27 Common Stock 68732 68732 D Stock Options 4.81 2015-05-06 4 A 0 31091 0.00 A 2024-04-27 Common Stock 31091 99823 D Reporting Person received such stock option in exchange for a stock option to purchase Tobira Therapeutics, Inc. ("Tobira") common stock in connection with the merger of Tobira into Issuer(the "Merger"). Pursuant to the terms of the Merger agreement each Tobira stock option assumed will be determined by multiplying the number of options by the exchange ratio of 1.43 and rounding down to the nearest whole number. 17,589 shares are vested and exercisable at any time. The remaining shares will vest and become exercisable accordingly: 405 shares on the 24th of each following month from May 24, 2015 through December 24, 2015; 1,735 shares on the 24th of each following month from January 24, 2016 through December 24, 2017; 2,080 shares on each of January 24, 2018, February 24, 2018, and March 24, 2018, subject to the terms of the Issuer's 2010 Stock Plan 9,447 shares are vested and exercisable at any time. The remaining shares will vest and become exercisable accordingly: 1,674 shares on the 24th of each following month through June 24, 2015; 1,673 shares on the 24th of each month from January 24, 2016 through December 24, 2015; 343 shares on the 24th of each following month from January 24, 2016 through December 24, 2017, subject to the terms of the Issuer's 2010 Stock Plan. /s/ Christopher Reilly, attorney-in-fact 2015-05-06