X0306 4 2015-05-04 0 0001311596 Tibira Therapeutics, Inc. TBRA 0001614724 Brosgart Carol L C/O TOBIRA THERAPEUTICS, INC. 701 GATEWAY BOULEVARD STE. 300 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Options (right to buy) 4.25 2015-05-04 4 A 0 4332 0.00 A 2020-02-24 Common Stock 4332 4332 D Stock Options (right to buy) 3.14 2015-05-04 4 A 0 4332 0.00 A 2020-11-30 Common Stock 4332 8664 D Stock Options (right to buy) 3.51 2015-05-04 4 A 0 4332 0.00 A 2023-02-06 Common Stock 4332 12996 D Stock Options (right to buy) 4.81 2015-05-04 4 A 0 18956 0.00 A 2024-04-27 Common Stock 18956 31952 D Reporting Person received such stock option in exchange for a stock option to purchase Tobira Therapeutics, Inc. ("Tobira") common stock in connection with the merger of Tobira into Issuer (the "Merger"). Pursuant to the terms of the Merger agreement each Tobira stock option assumed will be determined by multiplying the number of options by the exchange ratio of 1.43 and rounding down to the nearest whole number. The shares are fully vested and exercisable at any time. These shares shall never vest or become exercisable. 6,318 of the shares are vested and exercisable at any time. The remaining 12,638 shares will vest ratably over the next 32 months of continuous service beginning on June 1, 2015, subject to the terms of the Issuer's 2010 Stock Plan. /s/ Christopher Reilly, attorney-in-fact 2015-05-06