August 20, 2013

Via EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Austin Stephenson

Re: Regado Biosciences, Inc.

Registration Statement on Form S-1 (File No. 333-188209)

Ladies and Gentlemen:

Pursuant to Rule 461 of the Securities Act of 1933, as amended (the “Act”), Cowen and Company, LLC and BMO Capital Markets Corp., as representatives of the several underwriters, hereby join Regado Biosciences, Inc. in requesting that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 5:30 PM, Eastern Time, on August 21, 2013, or as soon thereafter as possible.

Pursuant to Rule 460 under the Act, please be advised that through the date hereof, the undersigned effected the distribution of approximately 793 copies of the Preliminary Prospectus dated May 29, 2013 to prospective underwriters, institutional investors, dealers, and others. In addition, we also wish to advise that the undersigned effected the distribution of approximately 231 copies of the Preliminary Prospectus dated August 19, 2013 to prospective underwriters, institutional investors, dealers, and others.

This is to further advise you that the underwriters have complied and will continue to comply with Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.

[Remainder of Page Intentionally Left Blank]

Very truly yours,
Cowen and Company, LLC BMO Capital Markets Corp.
By:	Cowen and Company, LLC
By:	/s/ Grant Miller Name: Grant Miller
	Title:   Managing Director
	By: BMO Capital Markets Corp.
By:	/s/ Lori Begley Name: Lori Begley
	Title:   Managing Director

[Signature Page to Underwriters’ Acceleration Request]