Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2015

Commitments and Contingencies.

Schedule of rent expense

The following table presents rent expense included in the Consolidated Statement of Operations (in thousands):

	Years Ended December 31,
	2015		2014		2013
Rent expense	$	2,268	$	2,268	$	1,377

Schedule of future commitments and obligations under operating lease

Future commitments and obligations under this operating lease to be satisfied as they become due over the term are as follows (in thousands):

The years ending December 31,
2016		2,350
2017		2,399
2018		2,459
2019		2,521
2020		2,584
Thereafter		12,452
Total	$	24,765

During 2015, the Company made payments in the amount of $1.7 million related to this operating lease.  In December 2015, the company signed a sublease to lease out a portion of office space. The sublessee is expected to move in during Q2 2016.  The term of the lease is for 3 years and the company will receive approximately $0.3 million in rental income annually.

Schedule of payments made in connection with the term loan with SVB

The following table presents payments made during the years ended December 31, 2013 in connection with the note payable to Symyx (in thousands):

	Year Ended December 31, 2013
	Principal		Interest		Total
Symyx payments	$	26,516	$	437	$	26,953

Schedule of Debt

The following table presents payments made during the years ended December 31, 2015 and 2014 for interest owed under the terms of the Loan Agreement (in thousands):

	Year Ended December 31, 2015
	Principal		Interest		Total
SVB payments	$	23,000	$	652	$	23,652
	Year Ended December 31, 2014
	Principal		Interest		Total
SVB payments	$	2,000	$	664	$	2,664