Condensed Consolidated Statements of Operations (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended
Mar. 31, 2015	Mar. 31, 2014
Revenues:
Product revenues	$ 8,821us-gaap_SalesRevenueGoodsNet	$ 7,348us-gaap_SalesRevenueGoodsNet
Research and development programs	3,784	5,043
Total revenues	12,605us-gaap_SalesRevenueNet	12,391us-gaap_SalesRevenueNet
Costs and operating expenses:
Cost of product revenues	4,670us-gaap_CostOfGoodsSold	3,390us-gaap_CostOfGoodsSold
Research and development	12,554us-gaap_ResearchAndDevelopmentExpense	20,835us-gaap_ResearchAndDevelopmentExpense
Sales, general and administrative	21,268	20,607
Restructuring charges	424us-gaap_RestructuringCharges	0us-gaap_RestructuringCharges
Total costs and operating expenses	38,916us-gaap_OperatingExpenses	44,832us-gaap_OperatingExpenses
Loss from operations	(26,311)us-gaap_OperatingIncomeLoss	(32,441)us-gaap_OperatingIncomeLoss
Other income (expense):
Interest and other income, net	263us-gaap_OtherNonoperatingIncomeExpense	235us-gaap_OtherNonoperatingIncomeExpense
Interest expense	(3,536)us-gaap_InterestExpense	(1,347)us-gaap_InterestExpense
Loss from equity method investment	(5,066)	(3,834)
Gain from change in fair value of warrant liability	0us-gaap_FairValueAdjustmentOfWarrants	688us-gaap_FairValueAdjustmentOfWarrants
(Loss) gain from change in fair value of derivative liabilities	(15)	2,018
Total other income (expense)	(8,354)us-gaap_NonoperatingIncomeExpense	(2,240)us-gaap_NonoperatingIncomeExpense
Net loss	$ (34,665)us-gaap_NetIncomeLoss	$ (34,681)us-gaap_NetIncomeLoss
Net loss per share, basic and diluted (in dollars per share)	$ (0.44)us-gaap_EarningsPerShareBasicAndDiluted	$ (0.50)us-gaap_EarningsPerShareBasicAndDiluted
Weighted average number of common shares used in loss per share computation, basic and diluted (in shares)	79,649,561	69,212,880

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