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Basic and Diluted Net Loss Per Share - Outstanding Shares of Potentially Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share (Detail)
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 32,690,995us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount 24,202,653us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
Options to purchase common stock    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 10,747,216us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_EmployeeStockOptionMember
11,142,893us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_EmployeeStockOptionMember
Common stock subject to repurchase    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 0us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= szym_CommonStockRepurchaseProgramMember
584us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= szym_CommonStockRepurchaseProgramMember
Restricted stock units    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 1,902,783us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_RestrictedStockUnitsRSUMember
2,218,578us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_RestrictedStockUnitsRSUMember
Warrants to purchase common stock    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 1,250,000us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_WarrantMember
1,250,000us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_WarrantMember
Shares of common stock to be issued upon conversion of the Notes    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Outstanding shares of potentially dilutive securities 18,790,996us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_ConvertibleDebtSecuritiesMember
9,590,598us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_StatementClassOfStockAxis
= us-gaap_ConvertibleDebtSecuritiesMember