Accrued Liabilities (Detail) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2014	Dec. 31, 2013
Payables and Accruals [Abstract]
Accrued compensation and related liabilities	$ 8,252	$ 7,959
Accrued interest	4,439	2,166
Accrued professional fees	698	350
Litigation Settlement, Amount	4,750	0
Accrued costs under Collaboration Agreement	1,732	2,629
Other accrued liabilities	1,806	1,901
Total accrued liabilities	$ 21,677	$ 15,005