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Income Taxes - Reconciling Items from Income Tax Computed at Statutory Federal Rate (Detail)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Federal income tax statutory rate 34.00% 34.00% 34.00%
State income taxes, net of federal benefits 4.50% 2.20% 1.60%
Revalued derivative liability 0.00% 0.00% 0.60%
Incentive stock option compensation (0.40%) (0.40%) (1.30%)
Research tax credits 1.40% 0.40% 0.80%
Other (0.10%) 0.00% 0.00%
Valuation allowance (37.50%) (36.20%) (35.70%)
Effective income tax rate from continuing operations 1.90% 0.00% 0.00%