Consolidated Statements of Operations - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product revenues	$ 3,483,000	$ 10,022,000	$ 12,917,000
Research and development programs	14,999,000	12,831,000	23,045,000
Total revenues	18,482,000	22,853,000	35,962,000
Costs and operating expenses:
Cost of product revenues	5,256,000	10,563,000	12,866,000
Research and development	31,116,000	48,094,000	81,680,000
Sales, general and administrative	43,741,000	62,041,000	72,621,000
Restructuring charges	1,412,000	4,953,000	3,514,000
Total costs and operating expenses	81,525,000	125,651,000	170,681,000
Loss from continuing operations before other income (expense):	(63,043,000)	(102,798,000)	(134,719,000)
Other income (expense):
Interest and other income, net	1,748,000	964,000	1,328,000
Interest expense	(13,545,000)	(14,160,000)	(11,711,000)
Debt conversion expense	(9,770,000)	0	(1,766,000)
Loss from equity method investments	(22,391,000)	(22,389,000)	(23,037,000)
Gain from change in fair value of derivative liabilities	82,000	1,000	8,744,000
Total other expense, net	(43,876,000)	(35,584,000)	(26,442,000)
Loss from continuing operations before income taxes	(106,919,000)	(138,382,000)	(161,161,000)
Benefit from income taxes	(2,062,000)	0	0
Loss from continuing operations	(104,857,000)	(138,382,000)	(161,161,000)
Income (loss) from discontinued operations	3,301,000	(3,065,000)	(980,000)
Net loss	$ (101,556,000)	$ (141,447,000)	$ (162,141,000)
Net income (loss) per share from continuing operations, per basic and diluted share (in dollars per share)	$ (1.22)	$ (1.73)	$ (2.13)
Net income (loss) from discontinued operations, per basic and diluted share (in dollars per share)	0.04	(0.03)	(0.01)
Net loss per share, basic and diluted (in dollars per share)	$ (1.18)	$ (1.76)	$ (2.14)
Weighted average number of common shares used in loss per share computation, basic and diluted (in shares)	85,952	80,165	75,879