Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Tables)

12 Months Ended

Dec. 31, 2016

As of December 31, 2016, our investment in equity method investments comprised as follows (in thousands):



SB Oils JV (Note 4)	$	42,373
Algenist Holdings, Inc. (Note 18)	1,483
Total equity method investments	$	43,856

Property, Plant and Equipment Estimated Ranges of Useful Lives

Depreciation is calculated on a straight-line basis over the following estimated ranges of useful lives:



Asset classification		Estimated useful life
Plant equipment		5 – 20 years
Lab equipment		3 – 7 years
Leasehold improvements		Shorter of useful life or life of lease
Building and improvements		7 – 20 years
Computer equipment and software		3 – 7 years
Furniture and fixtures and automobiles		5 – 7 years

Long-lived Assets by Geographic Areas [Table Text Block]

Geographic revenues are identified by the location in which the research and development program revenue and product sales were originated, and Long-lived assets, net of accumulated depreciation were as follows (in thousands).



	Year ended December 31,
	2016		2015		2014
United States	$	18,036	$	22,454	$	31,845
Brazil	446		399		4,117
Total revenues	$	18,482	$	22,853	$	35,962

			As of December 31,
			2016		2015
United States			$	24,157	$	25,973
Brazil			42,373		35,933
Total long-lived assets			$	66,530	$	61,906

Schedule of Accumulated Other Comprehensive Income (Loss)

The components of accumulated other comprehensive income (loss) consisted of the following (in thousands):



	Foreign Currency Translation Adjustments			Change in unrealized gain/loss on available-for-sale securities			Total Accumulated Other Comprehensive Loss
Balance at December 31, 2013	$	(3,880	)	$	86		$	(3,794	)
Current period other comprehensive loss	(6,908		)	(312		)	(7,220		)
Balance at December 31, 2014	(10,788		)	(226		)	(11,014		)
Current period other comprehensive loss	(11,545		)	228			(11,317		)
Balance at December 31, 2015	(22,333		)	2			(22,331		)
Current period other comprehensive loss	5,525			(2		)	5,523
Balance at December 31, 2016	$	(16,808	)	$	—		$	(16,808	)

Outstanding Shares of Potentially Dilutive Securities Excluded from Calculation of Dilutive Net Loss per Share

The following outstanding shares of potentially dilutive securities were excluded from the calculation of diluted net loss per share for the periods presented as the effect was anti-dilutive (in thousands):



	Year ended December 31,
	2016	2015	2014
Shares of common stock to be issued upon conversion of the Notes	15,152	18,791	18,791
Shares of common stock to be issued upon conversion of Series A Preferred Stock	13,375	—	—
Options to purchase common stock	12,707	11,901	13,740
Restricted stock units	1,274	1,884	1,812
Warrants to purchase common stock	750	750	1,250
Total	43,258	33,326	35,593