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Selected Quarterly Financial Data (Unaudited)
 12 Months Ended
Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]  
Selected Quarterly Financial Data (Unaudited)
SELECTED QUARTERLY FINANCIAL DATA (Unaudited)
We have presented the historical results of Algenist (See Note 18) as discontinued operations for all periods presented in this filing. The following table provides the selected quarterly financial data for 2016 and 2015 (in thousands, except per share amounts):
 
Quarter Ended
 
December 31,
2016
 
September 30,
2016
 
June 30,
2016
 
March 31,
2016
 
December 31,
2015
 
September 30,
2015
 
June 30,
2015
 
March 31,
2015
Revenues:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Product revenues
$
617

 
$
709

 
$
856

 
$
1,301

 
$
2,045

 
$
2,251

 
$
3,116

 
$
2,610

Research and development programs
4,219

 
3,601

 
3,592

 
3,587

 
3,348

 
2,266

 
3,433

 
3,784

Total revenues
4,836

 
4,310

 
4,448

 
4,888

 
5,393

 
4,517

 
6,549

 
6,394

Costs and operating expenses:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Cost of product revenues
2,218

 
884

 
850

 
1,304

 
2,788

 
2,411

 
3,014

 
2,350

Research and development
6,901

 
7,708

 
8,276

 
8,231

 
9,586

 
13,207

 
12,747

 
12,554

Sales, general and administrative
10,096

 
11,169

 
10,834

 
11,642

 
14,075

 
15,143

 
16,411

 
16,412

       Restructuring charges
(43
)
 
216

 
49

 
1,190

 
4,581

 
(21
)
 
(31
)
 
424

Total costs and operating expenses
19,172

 
19,977

 
20,009

 
22,367

 
31,030

 
30,740

 
32,141

 
31,740

Loss from continuing operations before other income (expense):
(14,336
)
 
(15,667
)
 
(15,561
)
 
(17,479
)
 
(25,637
)
 
(26,223
)
 
(25,592
)
 
(25,346
)
Other income (expense):
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Interest and other (expense) income, net
(2,544
)
 
(2,898
)
 
(3,157
)
 
(3,116
)
 
(3,314
)
 
(3,047
)
 
(3,534
)
 
(3,300
)
Loss from equity method investments
(5,783
)
 
(6,378
)
 
(5,358
)
 
(4,872
)
 
(4,098
)
 
(5,916
)
 
(7,309
)
 
(5,066
)
Debt conversion expense
(4,743
)
 
(3,242
)
 
(1,785
)
 
—

 
—

 
—

 
—

 
—

Total other income (expense)
(13,070
)
 
(12,518
)
 
(10,300
)
 
(7,988
)
 
(7,412
)
 
(8,963
)
 
(10,843
)
 
(8,366
)
Loss from continuing operations before income taxes
(27,406
)
 
(28,185
)
 
(25,861
)
 
(25,467
)
 
(33,049
)
 
(35,186
)
 
(36,435
)
 
(33,712
)
Benefit from income taxes
(223
)
 
(1,839
)
 
—

 
—

 
—

 
—

 
—

 
—

Loss from continuing operations
(27,183
)
 
(26,346
)
 
(25,861
)
 
(25,467
)
 
(33,049
)
 
(35,186
)
 
(36,435
)
 
(33,712
)
Income (loss) from discontinued operations, net of tax
71

 
5,852

 
(1,577
)
 
(1,045
)
 
(1,644
)
 
268

 
(736
)
 
(953
)
Net loss
$
(27,112
)
 
$
(20,494
)
 
$
(27,438
)
 
$
(26,512
)
 
$
(34,693
)
 
$
(34,918
)
 
$
(37,171
)
 
$
(34,665
)
Net income (loss) per share, basic and diluted:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Continuing operations
$
(0.30
)
 
$
(0.31
)
 
$
(0.31
)
 
$
(0.31
)
 
$
(0.41
)
 
$
(0.44
)
 
$
(0.45
)
 
$
(0.43
)
Discontinued operations
—

 
0.07

 
(0.02
)
 
(0.01
)
 
(0.02
)
 
0.01

 
(0.01
)
 
(0.01
)
Net loss per share, basic and diluted
$
(0.30
)
 
$
(0.24
)
 
$
(0.33
)
 
$
(0.32
)
 
$
(0.43
)
 
$
(0.43
)
 
$
(0.46
)
 
$
(0.44
)
Weighted average number of common shares used in loss per share computation, basic and diluted
91,582

 
85,837

 
84,380

 
81,950

 
80,600

 
80,298

 
80,098

 
79,650