Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product revenues	$ 709	$ 2,251	$ 2,866	$ 7,977
Research and development programs	3,601	2,266	10,780	9,483
Total revenues	4,310	4,517	13,646	17,460
Costs and operating expenses:
Cost of product revenues	884	2,411	3,038	7,775
Research and development	7,708	13,207	24,215	38,508
Sales, general and administrative	11,169	15,143	33,645	47,966
Restructuring charges	216	(21)	1,455	372
Total costs and operating expenses	19,977	30,740	62,353	94,621
Loss from continuing operations before other income (expense):	(15,667)	(26,223)	(48,707)	(77,161)
Other income (expense):
Interest and other income, net	562	317	1,174	715
Interest expense	(3,460)	(3,540)	(10,427)	(10,623)
Debt conversion expense	(3,242)	0	(5,027)	0
Loss from equity method investments	(6,378)	(5,916)	(16,608)	(18,291)
Change in fair value of derivative liabilities	0	176	82	27
Total other expense, net	(12,518)	(8,963)	(30,806)	(28,172)
Loss from continuing operations before income taxes	(28,185)	(35,186)	(79,513)	(105,333)
Benefit from income taxes	(1,839)	0	(1,839)	0
Loss from continuing operations before income taxes	(26,346)	(35,186)	(77,674)	(105,333)
Income (loss) from discontinued operations, net of tax	5,852	268	3,230	(1,421)
Net loss	$ (20,494)	$ (34,918)	$ (74,444)	$ (106,754)
Net income (loss) per share, basic and diluted:
Continuing operations (usd per share)	$ (0.31)	$ (0.44)	$ (0.93)	$ (1.31)
Discontinued operations (usd per share)	0.07	0.01	0.04	(0.02)
Net loss per share, basic and diluted (usd per share)	$ (0.24)	$ (0.43)	$ (0.89)	$ (1.33)
Weighted average number of common shares used in loss per share computation, basic and diluted (in shares)	85,837,223	80,297,757	84,062,169	80,017,436