Income Taxes - Reconciling Items from Income Tax Computed at Statutory Federal Rate (Detail)	12 Months Ended
Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Tax Disclosure [Abstract]
Federal income tax statutory rate	34.00%	34.00%	34.00%
State income taxes, net of federal benefits	2.20%	1.60%	4.10%
Revalued derivative liability	0.00%	0.60%	(1.80%)
Incentive stock option compensation	(0.40%)	(1.30%)	(1.60%)
Research tax credits	0.40%	0.80%	1.60%
Other	(0.10%)	0.30%	1.90%
Valuation allowance	(36.10%)	(36.00%)	(38.20%)
Effective income tax rate	0.00%	0.00%	0.00%

Effective Income Tax Rate Reconciliation Revaluation Of Derivative Liability

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References

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-Publisher FASB
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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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