Accrued Liabilities (Detail) - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Payables and Accruals [Abstract]
Accrued compensation and related liabilities	$ 6,178	$ 6,956
Accrued interest	4,439	3,495
Accrued professional fees	282	417
Accrued restructuring costs	0	1,348
Accrued costs under Collaboration Agreement	806	476
Other accrued liabilities	468	1,387
Total accrued liabilities	$ 12,173	$ 14,079