X0306 4 2018-12-06 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001309653 AZAB MOHAMMAD C/O XENON PHARMACEUTICALS INC 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2018-12-06 4 M 0 3086 3.07 A 57584 D Stock Option (Right to Buy) 3.07 2018-12-06 4 M 0 3086 0.00 D 2018-12-31 Common Shares 3086 0 D The exercise price was converted to U.S. dollars from $3.74 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the day of exercise. The shares subject to the option fully vested on December 31, 2011. No shares were sold by the Reporting Person in connection with the exercise and the common shares issued as a result of the exercise are subject to the terms of a lock-up agreement executed by the Reporting Person in favor of the underwriters of the Company's public offering in September 2018. Exhibit 24 - Power of Attorney /s/ Valerie, Attorney-in-fact 2018-12-10