The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 | 672,786 | 108,865 | SH | SOLE | 108,865 | 0 | 0 | |||
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 72,461,629 | 2,864,096 | SH | SOLE | 2,864,096 | 0 | 0 | |||
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 8,535,045 | 1,613,430 | SH | SOLE | 1,613,430 | 0 | 0 | |||
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 7,926,733 | 213,601 | SH | SOLE | 213,601 | 0 | 0 | |||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 331,660 | 155,709 | SH | SOLE | 155,709 | 0 | 0 | |||
| ALIGN TECHNOLOGY INC | COM | 016255101 | 5,294,069 | 31,389 | SH | SOLE | 31,389 | 0 | 0 | |||
| ALKERMES PLC | SHS | G01767105 | 12,708,931 | 242,560 | SH | SOLE | 242,560 | 0 | 0 | |||
| ANAPTYSBIO INC | COM | 032724106 | 40,735,508 | 603,489 | SH | SOLE | 603,489 | 0 | 0 | |||
| ANNEXON INC | COM | 03589W102 | 16,833,594 | 2,948,090 | SH | SOLE | 2,948,090 | 0 | 0 | |||
| BICARA THERAPEUTICS INC | COM | 055477103 | 16,341,614 | 550,408 | SH | SOLE | 550,408 | 0 | 0 | |||
| BICYCLE THERAPEUTICS PLC-ADR | SPONSORED ADS | 088786108 | 856,014 | 201,890 | SH | SOLE | 201,890 | 0 | 0 | |||
| BIOGEN INC | COM | 09062X103 | 30,308,681 | 140,279 | SH | SOLE | 140,279 | 0 | 0 | |||
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 39,068,500 | 682,777 | SH | SOLE | 682,777 | 0 | 0 | |||
| BIONTECH SE-ADR | SPONSORED ADS | 09075V102 | 1,825,083 | 19,614 | SH | SOLE | 19,614 | 0 | 0 | |||
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 5,532,693 | 229,763 | SH | SOLE | 229,763 | 0 | 0 | |||
| CAREDX INC | COM | 14167L103 | 15,158,295 | 531,870 | SH | SOLE | 531,870 | 0 | 0 | |||
| CELLDEX THERAPEUTICS INC | COM NEW | 15117B202 | 14,878,642 | 399,856 | SH | SOLE | 399,856 | 0 | 0 | |||
| COMPASS PATHWAYS PLC ADR | SPONSORED ADS | 20451W101 | 1,635,966 | 115,616 | SH | SOLE | 115,616 | 0 | 0 | |||
| COMPASS THERAPEUTICS INC | COM | 20454B104 | 12,771,670 | 5,831,813 | SH | SOLE | 5,831,813 | 0 | 0 | |||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 2,160,057 | 39,605 | SH | SOLE | 39,605 | 0 | 0 | |||
| CYTOKINETICS INC | COM NEW | 23282W605 | 2,742,692 | 32,195 | SH | SOLE | 32,195 | 0 | 0 | |||
| DISC MEDICINE INC | COM | 254604101 | 30,473,488 | 416,646 | SH | SOLE | 416,646 | 0 | 0 | |||
| DYNE THERAPEUTICS INC | COM | 26818M108 | 36,591,441 | 1,647,521 | SH | SOLE | 1,647,521 | 0 | 0 | |||
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 3,043,074 | 33,640 | SH | SOLE | 33,640 | 0 | 0 | |||
| EHEALTH INC | COM | 28238P109 | 2,209,368 | 1,482,797 | SH | SOLE | 1,482,797 | 0 | 0 | |||
| FIRST TRACKS BIOTHERAPEUTICS | ORD SHS | 337185102 | 12,142,199 | 603,489 | SH | SOLE | 603,489 | 0 | 0 | |||
| HUMANA INC | COM | 444859102 | 1,582,922 | 3,985 | SH | SOLE | 3,985 | 0 | 0 | |||
| INSMED INC | COM PAR $.01 | 457669307 | 44,138,548 | 413,980 | SH | SOLE | 413,980 | 0 | 0 | |||
| INSPIRE MEDICAL SYSTEMS INC | COM | 457730109 | 391,319 | 8,772 | SH | SOLE | 8,772 | 0 | 0 | |||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 22,032,229 | 5,296,209 | SH | SOLE | 5,296,209 | 0 | 0 | |||
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 959,530 | 1,787 | SH | SOLE | 1,787 | 0 | 0 | |||
| MIRUM PHARMACEUTICALS INC | NOTE 4.000% 5/0 | 604749AB7 | 40,834,953 | 348,808 | PRN | SOLE | 348,808 | 0 | 0 | |||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 3,053,349 | 18,117 | SH | SOLE | 18,117 | 0 | 0 | |||
| NEWAMSTERDAM PHARMA CO NV | ORDINARY SHARES | N62509109 | 1,503,327 | 44,359 | SH | SOLE | 44,359 | 0 | 0 | |||
| NOVOCURE LTD | ORD SHS | G6674U108 | 19,398,651 | 1,280,439 | SH | SOLE | 1,280,439 | 0 | 0 | |||
| NUVATION BIO INC | COM CL A | 67080N101 | 1,855,139 | 326,609 | SH | SOLE | 326,609 | 0 | 0 | |||
| ORUKA THERAPEUTICS INC - Restricted | COM | 687604108 | 3,192,573 | 33,546 | SH | SOLE | 33,546 | 0 | 0 | |||
| PROQR THERAPEUTICS NV | SHS EURO | N71542109 | 351,181 | 188,807 | SH | SOLE | 188,807 | 0 | 0 | |||
| PROTHENA CORP PLC | SHS | G72800108 | 11,191,487 | 1,143,155 | SH | SOLE | 1,143,155 | 0 | 0 | |||
| PTC THERAPEUTICS INC | COM | 69366J200 | 74,950,268 | 918,846 | SH | SOLE | 918,846 | 0 | 0 | |||
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 2,601,474 | 864,277 | SH | SOLE | 864,277 | 0 | 0 | |||
| SAGIMET BIOSCIENCES INC-A | COM SER A | 786700104 | 1,932,500 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | |||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 2,769,126 | 84,631 | SH | SOLE | 84,631 | 0 | 0 | |||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 18,908,594 | 864,986 | SH | SOLE | 864,986 | 0 | 0 | |||
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 9,475,311 | 1,391,382 | SH | SOLE | 1,391,382 | 0 | 0 | |||
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | 9,517,095 | 167,525 | SH | SOLE | 167,525 | 0 | 0 | |||
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 19,916,968 | 596,495 | SH | SOLE | 596,495 | 0 | 0 | |||
| UNITED THERAPEUTICS CORP | COM | 91307C102 | 33,911,514 | 62,587 | SH | SOLE | 62,587 | 0 | 0 | |||
| UROGEN PHARMA LTD | COM | M96088105 | 901,600 | 24,500 | SH | SOLE | 24,500 | 0 | 0 | |||
| VERASTEM INC | COM NEW | 92337C203 | 1,182,997 | 309,685 | SH | SOLE | 309,685 | 0 | 0 | |||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 3,099,184 | 51,345 | SH | SOLE | 51,345 | 0 | 0 | |||
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 826,927 | 104,410 | SH | SOLE | 104,410 | 0 | 0 | |||