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Related Party Transactions (Details)
1 Months Ended 3 Months Ended 108 Months Ended
Jul. 07, 2015
USD ($)
Sep. 30, 2011
Mar. 31, 2016
USD ($)
Mar. 31, 2015
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Jul. 31, 2015
USD ($)
Related Party Transaction              
Restricted cash     $ 600,000   $ 600,000 $ 600,000  
Revenue share agreements              
Related Party Transaction              
Revenue share expense     $ 847,000 $ 753,000      
Affiliate | Vertegen | License agreement              
Related Party Transaction              
Initial royalty rate on net sales of products under the agreement (as a percent)     6.00%   6.00%    
Reduced royalty rate on net sales of products following expiration of patents (as a percent)     3.00%   3.00%    
Royalty payments         $ 0    
Expenses in connection with preparation of patent applications         140,000    
Affiliate | Vertegen | License agreement | United States              
Related Party Transaction              
Period for reduced royalty rate     5 years        
Affiliate | Vertegen | License agreement | Rest of World              
Related Party Transaction              
Period for reduced royalty rate     5 years        
Investor | Letter agreement | Asia              
Related Party Transaction              
Period after IPO for voluntary continuation of committee to direct investment of funds 2 years            
Proceeds reclassified from restricted cash to cash and cash equivalents             $ 3,500,000
Restricted cash     $ 0   $ 0 $ 0  
Investor | Letter agreement | Series E-1 and E-2 convertible preferred stock | Asia              
Related Party Transaction              
Original amount of proceeds from preferred stock issued to related party, restricted to use for marketing and sales in Asia $ 5,000,000            
Dr. Philipp Lang | Revenue share agreements              
Related Party Transaction              
Revenue share expense     $ 249,000 $ 181,000      
Dr. Philipp Lang | Revenue share agreements | Minimum              
Related Party Transaction              
Required payment to related party from net revenues of current and planned products (as a percent)   0.875          
Dr. Philipp Lang | Revenue share agreements | Maximum              
Related Party Transaction              
Required payment to related party from net revenues of current and planned products (as a percent)   1.33